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Titolo:
Histological remodeling in an ovine heart failure model resembles human ischemic cardiomyopathy
Autore:
Ikeda, Y; Yutani, C; Huang, YF; Masuda, K; Yuasa, T; Kawaguchi, O; Hunyor, SN;
Indirizzi:
Natl Cardiovasc Ctr, Dept Pathol, Suita, Osaka 5658565, Japan Natl Cardiovasc Ctr Suita Osaka Japan 5658565 Suita, Osaka 5658565, Japan Royal N Shore Hosp, Dept Cardiol, Cardiac Technol Ctr, Sydney, NSW, Australia Royal N Shore Hosp Sydney NSW Australia hnol Ctr, Sydney, NSW, Australia
Titolo Testata:
CARDIOVASCULAR PATHOLOGY
fascicolo: 1, volume: 10, anno: 2001,
pagine: 19 - 27
SICI:
1054-8807(200101/02)10:1<19:HRIAOH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL-INFARCTION; PATHOLOGICAL HYPERTROPHY; CELLULAR HYPERPLASIA; CORONARY-ARTERY; RATS; APOPTOSIS; CONSTRICTION; MECHANISMS; MYOCYTES; COLLAGEN;
Keywords:
ischemic cardiomyopathy; ventricular remodeling; histopathology; chronic heart failure modal;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Ikeda, Y Natl Cardiovasc Ctr, Dept Pathol, 5-7-1 Fujishirodai, Suita, Osaka 5658565, Japan Natl Cardiovasc Ctr 5-7-1 Fujishirodai Suita Osaka Japan 5658565
Citazione:
Y. Ikeda et al., "Histological remodeling in an ovine heart failure model resembles human ischemic cardiomyopathy", CARDIO PATH, 10(1), 2001, pp. 19-27

Abstract

Staged coronary embolization, causing myocardial microinfarctions, has been shown in dogs and sheep to cause chronic ischemic heart failure (HF) thatresembles the hemodynamics of the human condition. However, its histopathological basis remains unclear. We examined the hypothesis that the ventricular remodeling seen in such sheep resembles the histopathology of human ischemic cardiomyopathy (ICM). Understanding the pathophysiology of this modelwill determine its place in the development of treatment strategies for HF. Global left ventricular (LV) damage resulting in HF was induced by stagedcoronary embolization in 11 sheep. Six others served as controls (normal control, NC). In HF sheep, the heart was harvested 6 months after LV ejection fraction (EF) had stabilized at < 35%. Histopathological profiles were compared in biventricular transverse sections at midpapillary level using computed image analysis. LV end-diastolic volume increased in the HF group from 84.9 +/- 29 to 122.4 +/- 30.3 ml (n = 11, P < .05), but myocytes across the LV wall in noninfarcted zones decreased (435.7 +/- 38.2 NC; 297.8 +/- 48.4/unit area HF; n = 11, P < .0001) as did myocyte nuclear density (990.5 +/- 51.5 NC; 677.5 +/- 12 1.1/mm(2) HF, n = 11, P < .0001). In contrast, LV replacement and interstitial fibrosis increased as did myocyte diameter in noninfarcted zones: 0.1 +/- 0.1 to 6.2 +/- 4.5% (P =.0049); 2.0 +/- 1.0 to 7.6 +/- 3.9% (P=.0149); and 10.0 +/- 0.5 to 15.9 +/- 2.2 mum (P < .0001), respectively. Although LV myocyte nuclear length increased (10.2 +/- 1.0 NC;12.2 +/- 0.9 mum HF, n = 11, P=.0006), right ventricular (RV) myocyte nuclear density and length did not alter. In this ovine chronic HF model, LV dilation and interstitial and myocyte remodeling resemble human ICM. (C) 2001Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:26:46