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Titolo:
Effect of corticosteroid therapy on serum and CSF malondialdehyde and antioxidant proteins in multiple sclerosis
Autore:
Keles, MS; Taysi, S; Sen, N; Aksoy, H; Akcay, F;
Indirizzi:
Ataturk Univ, Fac Med, Dept Biochem, Erzurum, Turkey Ataturk Univ Erzurum Turkey niv, Fac Med, Dept Biochem, Erzurum, Turkey Ataturk Univ, Fac Med, Dept Neurol, Erzurum, Turkey Ataturk Univ ErzurumTurkey Univ, Fac Med, Dept Neurol, Erzurum, Turkey
Titolo Testata:
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
fascicolo: 2, volume: 28, anno: 2001,
pagine: 141 - 143
SICI:
0317-1671(200105)28:2<141:EOCTOS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPID-PEROXIDATION PRODUCTS; CEREBROSPINAL-FLUID; CERULOPLASMIN; INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Keles, MS Ataturk Univ, Fac Med, Dept Biochem, Erzurum, Turkey Ataturk Univ Erzurum Turkey ed, Dept Biochem, Erzurum, Turkey
Citazione:
M.S. Keles et al., "Effect of corticosteroid therapy on serum and CSF malondialdehyde and antioxidant proteins in multiple sclerosis", CAN J NEUR, 28(2), 2001, pp. 141-143

Abstract

Objective: Multiple sclerosis (MS) is a disease characterised by perivascular infiltrates and demyelination of the white matter in the central nervous system. Although the precise cause of MS remains unknown, some investigations have been carried out on antioxidant mechanisms in these patients. Methods: In this study, malondialdehyde (MDA), as a lipid peroxidation marker,and ceruloplasmin (Cp) and transferrin (Trf), as antioxidant proteins, levels were determined in cerebrospinal fluid (CSF) and serum of 30 MS patients before and after corticosteroid therapy and in 20 control subjects. Transferrin and Cp levels were measured by the nephelometric method and MDA was measured spectrophotometrically. Results: Mean MDA(serum) and MDA(CSF) levels were found to be highest in the pretreatment group and lowest in the control group. Although there was no significant difference in terms of serum Trf level, serum Cp was found higher in pre- and posttreatment groups than in the control groups. Ceruloplasmin and Trf levels of CSF were not detectable using the nephelometric method. A significant correlation was found between MDA(CSF) and MDA(serum) in the pretreatment group (r=0.58). Conclusions: These data revealed that lipid peroxidation was increased in serum and particulary in CSF of MS patients and was reduced with corticosteroid therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:48:13