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Titolo:
Health and functional status of adult recipients 1 year after allogeneic haematopoietic stem cell transplantation
Autore:
Socie, G; Mary, JY; Esperou, H; Robert, DV; Aractingi, S; Ribaud, P; Devergie, A; Toubert, ME; Boudou, P; Cathelinau, B; Gluckman, E; Vexiau, P;
Indirizzi:
Hop St Louis, Serv Hematol Greffe de Moelle, F-75475 Paris 10, France Hop St Louis Paris France 10 Greffe de Moelle, F-75475 Paris 10, France Univ Paris 07, INSERM, U444, Ctr bioinformat, Paris, France Univ Paris 07Paris France INSERM, U444, Ctr bioinformat, Paris, France Hosp St Louis, Paris, France Hosp St Louis Paris FranceHosp St Louis, Paris, France
Titolo Testata:
BRITISH JOURNAL OF HAEMATOLOGY
fascicolo: 1, volume: 113, anno: 2001,
pagine: 194 - 201
SICI:
0007-1048(200104)113:1<194:HAFSOA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; OBSTRUCTIVE LUNG-DISEASE; TOTAL-BODY IRRADIATION; LONG-TERM SURVIVORS; VERSUS-HOST DISEASE; FOLLOW-UP; CHILDREN; LEUKEMIA; MANAGEMENT; BUSULFAN;
Keywords:
transplantation; late effects; irradiation; screening;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Socie, G Hop St Louis, Serv Hematol Greffe de Moelle, Ave Claude Vellefaux, F-75475Paris 10, France Hop St Louis Ave Claude Vellefaux Paris France 10 ris 10, France
Citazione:
G. Socie et al., "Health and functional status of adult recipients 1 year after allogeneic haematopoietic stem cell transplantation", BR J HAEM, 113(1), 2001, pp. 194-201

Abstract

Increasing numbers of patients are surviving after allogeneic haematopoietic stem cell transplantation (SCT). Among these patients, a number of late complications have been described but few data on the risk factors of theselong-term effects of SCT are available. We report the analysis on 105 adult patients, surviving free of haematological disease at a median time of 15months after SCT. At the time of screening, 52% had returned to work, general health status was normal in 67% and 47% were sexually active. Female patient gender odds ratio (OR) 2.9 (P = 0.01) and age >25 years (OR = 3.2. P = 0.02) were associated with non-return to work. Decreased general status was associated with chronic graft-versus-host disease (GvHD) (OR = 3.2, P = 0.009) and irradiation (OR = 3.6, P = 0.004). Sexual inactivity was associated with younger age (OR = 7.0, P = 0.0002) and chronic GVHD (OR = 3.3. P =0.006). Risk factors for altered pulmonary function tests included previous smoking habits, irradiation and chronic GvHD. Obstructive lung disease was associated with a previous history of asthma. Sicca syndrome and conjunctivitis were increased in patients with previous acute GVHD and cataracts were less frequent in patients with aplastic anaemia. Persistent impaired hair re-growth was less frequent in patients who received irradiation (OR = 0.18. P = 0.002) but increased in patients with previous acute GVHD (OR = 5.3, P = 0.007), Microalbuminuria was more frequent in irradiated patients (OR= 9.4, P = 0.05). Raised cholesterol was associated with age (OR = 20.8. P< 0.001), previous acute GVHD (OR = 4.7, P = 0.03), steroid use (OR = 6.3,P = 0.001) and familial hypercholesterolaemia (OR = 4.4, P = 0.04). Decreased bone density was associated with chronic GVHD (OR = 3.9. P = 0.001). Thus, using routine tests in adult patients we were able to detect significant numbers of non-symptomatic complications enabling early treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:23:20