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Titolo:
Microsatellite mutation of type II transforming growth factor-beta receptor is rare in atherosclerotic plaques
Autore:
Clark, KJ; Cary, NR; Grace, AA; Metcalfe, JC;
Indirizzi:
Univ Cambridge, MRC Ctr, Dept Oncol, Cambridge CB2 2QH, England Univ Cambridge Cambridge England CB2 2QH col, Cambridge CB2 2QH, England Univ Cambridge, Dept Biochem, Sect Cardiovasc Biol, Cambridge CB2 2QH, England Univ Cambridge Cambridge England CB2 2QH iol, Cambridge CB2 2QH, England Guys Kings & St Thomas Hosp Med Sch, Dept Forens Med, Directorate Forens Pathol, London, England Guys Kings & St Thomas Hosp Med Sch London England hol, London, England
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 4, volume: 21, anno: 2001,
pagine: 555 - 559
SICI:
1079-5642(200104)21:4<555:MMOTIT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMERICAN-HEART-ASSOCIATION; SMOOTH-MUSCLE CELLS; TGF-BETA; VASCULAR-LESIONS; CANCER CELLS; GENE; INSTABILITY; ARTERIOSCLEROSIS; DEFINITION; COMMITTEE;
Keywords:
transforming growth factor-beta; type II transforming growth factor-beta receptors; microsatellite mutation; atherosclerosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Clark, KJ Univ Cambridge, MRC Ctr, Dept Oncol, Hills Rd, Cambridge CB2 2QH, England Univ Cambridge Hills Rd Cambridge England CB2 2QH 2QH, England
Citazione:
K.J. Clark et al., "Microsatellite mutation of type II transforming growth factor-beta receptor is rare in atherosclerotic plaques", ART THROM V, 21(4), 2001, pp. 555-559

Abstract

A somatic mutation within a microsatellite polyA tract in the coding region of the type II transforming growth factor (TGF)-beta receptor gene was reported to occur in human atherosclerotic and restenotic lesions. This mutation occurs frequently in colorectal cancer with the replication error repair phenotype and results in loss of sensitivity to the growth inhibitory effects of TGF-beta in cells from the tumors. The mutation was proposed to account for the clonal expansion of vascular smooth muscle cells observed in atherosclerotic plaques, through loss of the growth inhibitory effect of TGF-beta. The frequency of the mutation and the extent of clonal expansion of the mutated cells have major implications for the mechanism of atherogenesis and therapeutic strategies. We analyzed a set of 22 coronary arterial and9 aortic samples containing early to advanced atherosclerotic lesions fbr the mutation in the type II TGF-beta receptor polyA tract. Only 1 coronary arterial sample from an advanced lesion showed detectable amounts of the mutation, present at a low level (8% of the DNA sample). The data imply that the mutation occurs only at low frequency and is not a major mechanistic contributor to the development of atherosclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 07:09:39