Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Paraoxonase and atherosclerosis
Autore:
Durrington, PN; Mackness, B; Mackness, MI;
Indirizzi:
Univ Manchester, Manchester Royal Infirm, Dept Med, Manchester M13 9WL, Lancs, England Univ Manchester Manchester Lancs England M13 9WL M13 9WL, Lancs, England
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 4, volume: 21, anno: 2001,
pagine: 473 - 480
SICI:
1079-5642(200104)21:4<473:PAA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; CORONARY-ARTERY DISEASE; DEPENDENT DIABETES-MELLITUS; CHOLESTERYL ESTER TRANSFER; BINDING CASSETTE TRANSPORTER-1; APOLIPOPROTEIN-A-I; AUSTRIAN STROKE PREVENTION; CHRONIC-RENAL-FAILURE; ACUTE-PHASE RESPONSE; GULF-WAR VETERANS;
Keywords:
paraoxonase; lipid peroxidation; high density lipoproteins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
119
Recensione:
Indirizzi per estratti:
Indirizzo: Durrington, PN Univ Manchester, Manchester Royal Infirm, Dept Med, Oxford Rd, Manchester M13 9WL, Lancs, England Univ Manchester Oxford Rd ManchesterLancs England M13 9WL
Citazione:
P.N. Durrington et al., "Paraoxonase and atherosclerosis", ART THROM V, 21(4), 2001, pp. 473-480

Abstract

There is considerable evidence that the antioxidant activity of high density lipoprotein (HDL) is largely due to the paraoxonase-1(PON1) located on it. Experiments with transgenic PON1 knockout mice indicate the potential for PON1 to protect against atherogenesis. This protective effect of HDL against low density lipoprotein (LDL) lipid peroxidation is maintained longer than is the protective effect of antioxidant vitamins and could thus be moreimportant. There is evidence that the genetic polymorphisms of PON1 least able to protect LDL against lipid peroxidation are overrepresented in coronary heart disease, particularly in association with diabetes. However, these polymorphisms explain only part of the variation in serum PON1 activity; thus, a more critical test of the hypothesis is likely to be whether low serum PON1 activity is associated with coronary heart disease. Preliminary case-control evidence suggests that this is indeed the case and, thus, that the quest for dietary and pharmacological means of modifying serum PON1 activity may allow the oxidant model of atherosclerosis to be tested in clinical trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 00:32:36