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Titolo:
Uptake, transport, and delivery of antimicrobial agents by human polymorphonuclear neutrophils
Autore:
Mandell, GL; Coleman, E;
Indirizzi:
Univ Virginia, Hlth Syst, Div Infect Dis, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA
Titolo Testata:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
fascicolo: 6, volume: 45, anno: 2001,
pagine: 1794 - 1798
SICI:
0066-4804(200106)45:6<1794:UTADOA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
STAPHYLOCOCCUS-AUREUS; ANTIBIOTICS; LEUKOCYTES; CELLS; KETOLIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Mandell, GL Univ Virginia, Hlth Syst, Div Infect Dis, POB 801341, Charlottesville, VA 22908 USA Univ Virginia POB 801341 Charlottesville VA USA 229082908 USA
Citazione:
G.L. Mandell e E. Coleman, "Uptake, transport, and delivery of antimicrobial agents by human polymorphonuclear neutrophils", ANTIM AG CH, 45(6), 2001, pp. 1794-1798

Abstract

Polymorphonuclear neutrophils (PMN) are attracted to sites of infection. They have the potential to deliver antimicrobial agents to these sites if the agents enter the cells and do not alter migration. Penicillin G did not enter cells and was not transported by PMN, We found that azithromycin, ciprofloxacin, levofloxacin, moxifloxacin, and telithromycin were concentrated in PMN and transported toward a chemoattractant. These antimicrobial agentswere released from the PMN and inhibited the growth of bacteria on test plates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 06:17:01