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Titolo:
Male sex predominance in Chlamydia trachomatis sexually acquired reactive arthritis: are women more protected by anti-chlamydia antibodies?
Autore:
Bas, S; Scieux, C; Vischer, TL;
Indirizzi:
Univ Hosp, Dept Internal Med, Div Rheumatol, CH-1211 Geneva 14, Switzerland Univ Hosp Geneva Switzerland 14 heumatol, CH-1211 Geneva 14, Switzerland St Louis Hosp, Bacteriol Lab, Paris, France St Louis Hosp Paris FranceSt Louis Hosp, Bacteriol Lab, Paris, France
Titolo Testata:
ANNALS OF THE RHEUMATIC DISEASES
fascicolo: 6, volume: 60, anno: 2001,
pagine: 605 - 611
SICI:
0003-4967(200106)60:6<605:MSPICT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
4TH INTERNATIONAL-WORKSHOP; GENITAL-TRACT INFECTION; REITERS-SYNDROME; YERSINIA-ENTEROCOLITICA; ANKYLOSING-SPONDYLITIS; IMMUNOBLOT ANALYSIS; RHEUMATIC DISEASES; MEMBRANE-PROTEINS; IMMUNE-RESPONSE; IGA RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Bas, S Univ Hosp, Dept Internal Med, Div Rheumatol, CH-1211 Geneva 14, Switzerland Univ Hosp Geneva Switzerland 14 l, CH-1211 Geneva 14, Switzerland
Citazione:
S. Bas et al., "Male sex predominance in Chlamydia trachomatis sexually acquired reactive arthritis: are women more protected by anti-chlamydia antibodies?", ANN RHEUM D, 60(6), 2001, pp. 605-611

Abstract

Objective-To determine whether the humoral anti-chlamydia antibody response might be related to the ineffective bacterial elimination seen in patients with Chlamydia trachomatis reactive arthritis, particularly in men, who have a higher prevalence of the disease than women. Methods-The number and specificity of the antibody responses to 27 different C trachomatis antigens were determined by western blots in serum samplesfrom patients with C trachomatis urogenital infection, with and without reactive arthritis, with a special regard to the sex of the patients. Results-Patients with reactive arthritis had antibodies to significantly fewer chlamydia antigens than those with urethritis only. Antibodies from men recognised significantly fewer antigens than antibodies from women. The IgA class antibodies were slightly more relevant than those of the IgG classfor differentiation of patients with reactive arthritis from those with uncomplicated genitourinary infection. Conclusions-In patients with acute C trachomatis infection the developmentof reactive arthritis may be related, particularly in men, to a deficient humoral response, to antigens which perhaps play a part in the clearance ofthe bacteria. Men who cannot generate antibodies to a large number of antigens may be less able to contain the local infection, allowing a wide systemic dissemination of the organisms to the joints.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 13:14:32