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Titolo:
Different sensitivities to competitive inhibition of benzodiazepine receptor binding of C-11-iomazenil and C-11-flumazenil in rhesus monkey brain
Autore:
Inoue, O; Hosoi, R; Kobayashi, K; Itoh, T; Gee, A; Suzuki, K;
Indirizzi:
Osaka Univ, Fac Med, Sch Allied Hlth Sci, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 lth Sci, Suita, Osaka 5650871, Japan Nippon Med Sch, Ctr Informat Sci, Tokyo, Japan Nippon Med Sch Tokyo Japan ppon Med Sch, Ctr Informat Sci, Tokyo, Japan Aarhus Univ Hosp, PET Ctr, DK-8000 Aarhus, Denmark Aarhus Univ Hosp Aarhus Denmark DK-8000 PET Ctr, DK-8000 Aarhus, Denmark Natl Inst Radiol Sci, Chiba, Japan Natl Inst Radiol Sci Chiba JapanNatl Inst Radiol Sci, Chiba, Japan
Titolo Testata:
ANNALS OF NUCLEAR MEDICINE
fascicolo: 2, volume: 15, anno: 2001,
pagine: 137 - 139
SICI:
0914-7187(200104)15:2<137:DSTCIO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; IN-VIVO; IOMAZENIL; RAT;
Keywords:
C-11-iomazenil; C-11-flumazenil; benzodiazepine receptors; rhesus monkey; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Inoue, O Osaka Univ, Fac Med, Sch Allied Hlth Sci, 1-7 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 1-7 Yamadaoka Suita Osaka Japan 5650871 5650871, Japan
Citazione:
O. Inoue et al., "Different sensitivities to competitive inhibition of benzodiazepine receptor binding of C-11-iomazenil and C-11-flumazenil in rhesus monkey brain", ANN NUCL M, 15(2), 2001, pp. 137-139

Abstract

The in vivo binding kinetics of C-11-iomazenil were compared with those ofC-11-flumazenil binding in rhesus monkey brain. The monkey was anesthetized with ketamine and intravenously injected with either C-11-iomazenil or C-11-flumazenil in combination with the coadministration of different doses of non-radioactive flumazenil (0, 5 and 20 mug/kg). The regional distribution of C-11-iomazenil in the brain was similar to that of C-11-flumazenil. but the sensitivity of C-11-iomazenil binding to competitive inhibition by non-radioactive flumazenil was much less than that of C-11-flumazenil binding. A significant reduction in C-11-flumazenil binding in the cerebral cortexwas observed with 20 mug/kg of flumazenil, whereas a relatively smaller inhibition of C-11-iomazenil binding in the same region was observed with thesame dose of flumazenil. These results suggest that C-11-flumazenil may bea superior radiotracer for estimating benzodiazepine receptor occupancy inthe intact brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:36:35