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Titolo:
Esophageal hypomotility in systemic sclerosis: Close relationship with pulmonary involvement
Autore:
Kinuya, K; Nakajima, K; Kinuya, S; Michigishi, T; Tonami, N; Takehara, K;
Indirizzi:
Tonami Gen Hosp, Dept Radiol, Tonami, Toyama 9391395, Japan Tonami Gen Hosp Tonami Toyama Japan 9391395 Tonami, Toyama 9391395, Japan Kanazawa Univ Hosp, Dept Nucl Med, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Hosp Kanazawa Ishikawa Japan 920 azawa, Ishikawa 920, Japan Kanazawa Univ Hosp, Dept Dermatol, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Hosp Kanazawa Ishikawa Japan 920 azawa, Ishikawa 920, Japan
Titolo Testata:
ANNALS OF NUCLEAR MEDICINE
fascicolo: 2, volume: 15, anno: 2001,
pagine: 97 - 101
SICI:
0914-7187(200104)15:2<97:EHISSC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIONUCLIDE TRANSIT; CLINICAL CORRELATIONS; TOPOISOMERASE-I; SCLERODERMA; SCINTIGRAPHY; DYSFUNCTION; MANOMETRY; MOTILITY; AUTOANTIBODIES; PATHOGENESIS;
Keywords:
esophageal scintigraphy; system sclerosis; esophageal hypomotility; antitopoisomerase I antibody; pulmonary involvement;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Kinuya, K Tonami Gen Hosp, Dept Radiol, 1-61 Shintomicho, Tonami, Toyama 9391395, Japan Tonami Gen Hosp 1-61 Shintomicho Tonami Toyama Japan 9391395 pan
Citazione:
K. Kinuya et al., "Esophageal hypomotility in systemic sclerosis: Close relationship with pulmonary involvement", ANN NUCL M, 15(2), 2001, pp. 97-101

Abstract

Purpose: Esophageal motility was assessed in patients with systemic sclerosis (SSc) by scintig raphy and compared with (i) extent of scleroderma, (ii) duration of disease, (iii) index of antitopoisomerase I antibody (topo I), and (iv) pulmonary involvement. Methods: A multiple-swallow test was performed in 47 patients with SSc in the supine position with Tc-99m-DTPA. A region of interest on the entire esophagus was defined and the retention ratio (RR) was calculated From a timeactivity curve. Results: Patients with diffuse scleroderma had higher RRs than those with limited scleroderma (48.8% vs. 30.0%; p < 0.05). There was no correlation between the RRs and the duration of disease. Patients with positive topo I had higher RRs than those who were negative (53.8% vs. 29.7%; p < 0.05), Patients with reduced % diffusion capacity for carbon monoxide (%,DLCO) had higher RRs than those with normal %DLCO (40.5% vs. 19.6%; p = 0.03). Patients with reduced Ic vital capacity (%VC) had higher RRs than those with normal %VC (54,64% vs. 25.0%; p <0.005). Patients with pulmonary fibrosis had higher RRs than those: who were negative (58.5% vs. 20.3%; p < 0.00005). Conclusion: Esophageal dysfunction in patients with SSc showed a correlation with the extent of scleroderma, positive topo I, and pulmonary involvement. The RR can be an objective clinical marker for the severity of organ fibrosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:28:32