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Titolo:
alpha-1 and alpha-2 adrenergic antagonists relieve thermal hyperalgesia inexperimental mononeuropathy from chronic constriction injury
Autore:
Hord, AH; Denson, DD; Stowe, B; Haygood, RM;
Indirizzi:
Emory Univ, Sch Med, Dept Anesthesiol, Div Pain Med, Atlanta, GA 30322 USAEmory Univ Atlanta GA USA 30322 siol, Div Pain Med, Atlanta, GA 30322 USA
Titolo Testata:
ANESTHESIA AND ANALGESIA
fascicolo: 6, volume: 92, anno: 2001,
pagine: 1558 - 1562
SICI:
0003-2999(200106)92:6<1558:AAAAAR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETICALLY MAINTAINED PAIN; PERIPHERAL NEUROPATHY; MECHANICAL ALLODYNIA; NERVE INJURY; RATS; SYMPATHECTOMY; PHENTOLAMINE; ACTIVATION; MODEL; ADRENOCEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Hord, AH Emory Univ, Sch Med, Dept Anesthesiol, Div Pain Med, 1364 CliftonRd NE, Atlanta, GA 30322 USA Emory Univ 1364 Clifton Rd NE Atlanta GA USA 30322 , GA 30322 USA
Citazione:
A.H. Hord et al., "alpha-1 and alpha-2 adrenergic antagonists relieve thermal hyperalgesia inexperimental mononeuropathy from chronic constriction injury", ANESTH ANAL, 92(6), 2001, pp. 1558-1562

Abstract

aPhentolamine, a nonspecific alpha1- and alpha2-adrenergic antagonist, relieves pain in patients with reflex sympathetic dystrophy We sought to determine whether phentolamine, prazosin (alpha1 antagonist), or SKF86466 (alpha2 antagonist) relieve thermal hyperalgesia in rats with neuropathic pain. Four days after producing a chronic constriction injury (CCI), thermal hyperalgesia was tested by measuring paw withdrawal latency (PWL). After injection of phentolamine, prazosin, or SWF86466 each at doses of 1, 2, or 5 mg/kg, PWL tests were measured at 5 min and repeated at 15-min intervals for 1 h. Phentolamine, prazosin, and SKF864661, 2, and 5 mg/kg presided statistically significant analgesia in rats with CCI for at least 65 min. PWL did notreturn to baseline levels after 1 or 2 mg/kg of prazosin or SKF86466 but did so after 35 min after phentolanine 2 mg/kg. After 5 mg/kg PWL returned to preoperative values between 5 and 50 min for phentolamine, at 35 and 65 min for prazosin, and at 50 min for SKF86466. We conclude that both alpha1 and alpha2 peripheral receptors of the sympathetic nervous system are involved in the thermal hyperalgesia caused by CCI and that thermal hyperalgesia can be reversed by both alpha1 and alpha2 antagonists in a dose-dependent manner.

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Documento generato il 26/01/21 alle ore 04:42:01