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Titolo:
Direct tramadol application on sciatic nerve inhibits spinal somatosensoryevoked potentials in rats
Autore:
Tsai, YC; Chang, PJ; Jou, IM;
Indirizzi:
Natl Chung Cheng Univ, Med Coll & Hosp, Dept Anesthesiol, Tainan, Taiwan Natl Chung Cheng Univ Tainan Taiwan p, Dept Anesthesiol, Tainan, Taiwan Natl Chung Cheng Univ, Med Coll & Hosp, Dept Orthoped, Tainan, Taiwan NatlChung Cheng Univ Tainan Taiwan Hosp, Dept Orthoped, Tainan, Taiwan
Titolo Testata:
ANESTHESIA AND ANALGESIA
fascicolo: 6, volume: 92, anno: 2001,
pagine: 1547 - 1551
SICI:
0003-2999(200106)92:6<1547:DTAOSN>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
AFFERENT-FIBERS; LIDOCAINE; MEPERIDINE; FENTANYL; INVITRO; BLOCK; SUFENTANIL; CONDUCTION; INJECTION; MORPHINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Jou, IM Natl Cheng Kung Univ Hosp, Dept Orthoped, 138 Shengi Li Rd, Tainan704, Taiwan Natl Cheng Kung Univ Hosp 138 Shengi Li Rd Tainan Taiwan 704 iwan
Citazione:
Y.C. Tsai et al., "Direct tramadol application on sciatic nerve inhibits spinal somatosensoryevoked potentials in rats", ANESTH ANAL, 92(6), 2001, pp. 1547-1551

Abstract

We sought to determine the possible neural conduction blockade of tramadoland whether there is evidence of localized neural toxicity with spinal somatosensory evoked potential (SSEP) measurements. Male Wistar rats were used. SSEP, elicited by supramaximally stimulating the hind paw and recorded from the thoracolumbar and the first and second lumbar interspinous ligaments, was monitored. SSEPs were obtained before drug application as the pretreatment baseline and measured every 15 min after treatment for 2 h and at 60-min intervals thereafter until SSEP returned to baseline or for another 4 h. Two small strips of Gelfoam (0.6 x 1.0 cm(2)) soaked with the drug were placed under and over the left sciatic nerve for a 30-min period. Gelfoam was prepared with tramadol hydrochloride (Tramal; the US trade name is Ultram) 5, 2.5, and 1.25 mg, diluted if needed with saline to a total volume of 100 muL (5%, 2.5%, and 1.25%, respectively). The control data were obtained from the right side limb with normal saline by following the same method. Spinal SSEPs were measured after 48 h to detect the late neural damage. The results showed that direct tramadol application on sciatic nerves dose-dependently reduced both the amplitude and conduction velocity of SSEPs when compared with the pretreatment baseline. All SSEPs returned to pretreatment baseline, and no significant changes of SSEP between bilateral limbs were noted at the 48-h measurements. No evidence of irreversible conduction blockade indicative of local neural toxicity was seen. Pretreatment with naloxone1 mg/kg failed to block the changes of SSEP produced by 2.5% tramadol 100 muL. We conclude that tramadol exerts a local anesthetic-type effect on peripheral nerves.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:31:54