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Titolo:
Gender does not influence epsilon-aminocaproic acid concentrations in adults undergoing cardiopulmonary bypass
Autore:
Butterworth, J; James, RL; Lin, YA; Bennett, J; Prielipp, RC;
Indirizzi:
Wake Forest Univ, Sch Med, Dept Anesthesiol, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA
Titolo Testata:
ANESTHESIA AND ANALGESIA
fascicolo: 6, volume: 92, anno: 2001,
pagine: 1384 - 1390
SICI:
0003-2999(200106)92:6<1384:GDNIEA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CREATININE CLEARANCE; PHARMACOKINETICS; PHARMACODYNAMICS; DRUGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Butterworth, J Wake Forest Univ, Sch Med, Dept Anesthesiol, Med Ctr Blvd, Winston Salem, NC 27157 USA Wake Forest Univ Med Ctr Blvd Winston Salem NC USA 27157 SA
Citazione:
J. Butterworth et al., "Gender does not influence epsilon-aminocaproic acid concentrations in adults undergoing cardiopulmonary bypass", ANESTH ANAL, 92(6), 2001, pp. 1384-1390

Abstract

Epsilon-aminocaproic acid (epsilon -ACA) is administered to cardiac surgery patients to reduce blood transfusions. Highly water-soluble drugs, such as epsilon -ACA, often have larger distribution volumes in males than in females. We hypothesized that epsilon -ACA concentrations using this dosing scheme would differ by gender because of differences in body composition and weight-adjusted volumes of distribution. Ten men and 10 women undergoing elective coronary artery surgery with cardiopulmonary bypass (CPB) received a50 mg/kg epsilon -ACA initial dose over 20 min and a 25 mg kg(-1).h(-1).epsilon -ACA maintenance infusion for 4 h. The area under the epsilon -ACA arterial concentration versus time curves was compared by using analysis of variance. Measured epsilon -ACA concentrations were smaller than predicted by the published model, but the area under the concentration versus time curves was not significantly different between men and women. Combining the present concentration data with that previously published, our updated two-compartment model included the following estimated population pharmacokineticvalues: V-1 (11.8 L pre-CPB, 14.9 L during and after CPB), V-2 (12.0 L pre-CPB, 15.0 L during and after CPB), Cl-1 (0.125 L/min pre-CPB, 0.037 L/min during CPB, 0.156 L/min after CPB), Cl-2 (0.155 L/min pre-CPB, 0.013 L/min during CPB, 0.193 L/min after CPB).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 03:39:17