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Titolo:
Epidural ropivacaine hydrochloride during labour: protein binding, placental transfer and neonatal outcome
Autore:
Porter, JM; Kelleher, N; Flynn, R; Shorten, GD;
Indirizzi:
Natl Univ Ireland Univ Coll Cork, Cork Univ Hosp, Dept Anaesthesia & Intens Care Med, Cork, Ireland Natl Univ Ireland Univ Coll Cork Cork Ireland s Care Med, Cork, Ireland Natl Univ Ireland Univ Coll Cork, Cork Univ Hosp, Dept Biochem, Cork, Ireland Natl Univ Ireland Univ Coll Cork Cork Ireland pt Biochem, Cork, Ireland Bons Secours Hosp, Dept Anaesthesia, Cork, Ireland Bons Secours Hosp Cork Ireland rs Hosp, Dept Anaesthesia, Cork, Ireland
Titolo Testata:
ANAESTHESIA
fascicolo: 5, volume: 56, anno: 2001,
pagine: 418 - 423
SICI:
0003-2409(200105)56:5<418:ERHDLP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTIVE CESAREAN-SECTION; ALPHA-1-ACID GLYCOPROTEIN; EXTRADURAL ANALGESIA; BASIC DRUGS; BUPIVACAINE; ANESTHESIA; PHARMACOKINETICS; INFUSION; SYSTEM;
Keywords:
anaesthetics, local, ropivacaine; anaesthetic techniques, regional, epidural; blood, plasma protein binding, alpha-1-glycoprotein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Porter, JM Natl Univ Ireland Univ Coll Cork, Cork Univ Hosp, Dept Anaesthesia & Intens Care Med, Cork, Ireland Natl Univ Ireland Univ Coll Cork Cork Ireland Cork, Ireland
Citazione:
J.M. Porter et al., "Epidural ropivacaine hydrochloride during labour: protein binding, placental transfer and neonatal outcome", ANAESTHESIA, 56(5), 2001, pp. 418-423

Abstract

This study was undertaken: (i) to quantify the effects of labour and epidural analgesia on plasma alpha (1)-acid glycoprotein concentration, (ii) to examine the effects of changes in plasma oil-acid glycoprotein concentration on plasma protein binding and placental transfer of ropivacaine, and (iii) to examine the association between umbilical venous ropivacaine concentration and neurobehavioural function in the neonate. Multiparous patients undergoing induction of labour received a continuous epidural infusion of 0.1%ropivacaine following an epidural bolus. A significant association was demonstrated between maternal plasma cll-acid glycoprotein concentration and 1/free fraction of ropivacaine 60 min after starting ropivacaine administration (r(2) = 0.77) but not at delivery. No significant correlation was demonstrable between maternal unbound ropivacaine concentration and either neonatal (cord) ropivacaine concentration or UV/MV (a measure of placental transfer). Thirty minutes after delivery, 9/10 neonates had neurological and adaptive capacity scores <35, whereas only three infants had scores <35 at 2 h. All scores exceeded 35 16 h after delivery. No association between mean (SD) umbilical venous ropivacaine concentration [0.09 (0.08) mg.l(-1)] and neurological and adaptive capacity scores was demonstrated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 00:35:56