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Titolo:
Renal sympathetic nerve regulation to heating is altered in rats with heart failure
Autore:
Kenney, MJ; Musch, TI; Weiss, ML;
Indirizzi:
Kansas State Univ, Dept Anat & Physiol, Manhattan, KS 66506 USA Kansas State Univ Manhattan KS USA 66506 Physiol, Manhattan, KS 66506 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 6, volume: 280, anno: 2001,
pagine: H2868 - H2875
SICI:
0363-6135(200106)280:6<H2868:RSNRTH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL-INFARCTION; PARAVENTRICULAR NUCLEUS; SYSTEM; RESPONSES; EXERCISE; ACTIVATION; STRESS; ABNORMALITIES; HYPERACTIVITY; HYPERTHERMIA;
Keywords:
myocardial infarction; blood flow; paraventricular nucleus; hypothalamus; ibotenic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Kenney, MJ Kansas State Univ, Dept Anat & Physiol, 1600 Denison Ave,Coles Hall,Rm 228, Manhattan, KS 66506 USA Kansas State Univ 1600 Denison Ave,Coles Hall,Rm 228 Manhattan KS USA 66506
Citazione:
M.J. Kenney et al., "Renal sympathetic nerve regulation to heating is altered in rats with heart failure", AM J P-HEAR, 280(6), 2001, pp. H2868-H2875

Abstract

Heart failure (HF) alters the regulation of basal sympathetic nerve discharge (SND); however, the effect of HF on SND responses to acute stress is not well established. In the present study, renal SND responses to hyperthermia were determined in chloralose-anesthetized HF rats and in sham controls. Whole body heating (colonic temperature increased from 38 to 41 degreesC) was used as an acute stressor because increased internal body temperature provides a potent stimulus to the sympathetic nervous system. Left ventricular end-diastolic pressure and the right ventricular wt-to-body wt ratio were increased (P < 0.05) in HF compared with sham rats. The following observations were made: 1) renal sympathoexcitatory responses to heating were significantly reduced in HF compared with sham rats, 2) renal blood flow remained unchanged from control levels during heating in HF rats but was significantly reduced in sham rats, and 3) renal SND responses to heating were significantly higher in HF rats with bilateral lesions of the hypothalamic paraventricular nucleus (PVN) compared with sham PVN-lesioned HF rats. These results demonstrate a marked attenuation in the responsiveness of renal SND to heating in HF rats and suggest that HF alters the organization of neural pathways mediating SND responses to heating.

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Documento generato il 29/03/20 alle ore 15:15:36