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Titolo:
Myocardial ischemia selectively depletes cardiolipin in rabbit heart subsarcolemmal mitochondria
Autore:
Lesnefsky, EJ; Slabe, TJ; Stoll, MSK; Minkler, PE; Hoppel, CL;
Indirizzi:
Louis Stokes VA Med Ctr, Cardiol Sect, Med Serv 111W, Cleveland, OH 44106 USA Louis Stokes VA Med Ctr Cleveland OH USA 44106 W, Cleveland, OH 44106 USA Louis Stokes VA Med Ctr, Ctr Geriatr Res Educ & Clin, Cleveland, OH 44106 USA Louis Stokes VA Med Ctr Cleveland OH USA 44106 n, Cleveland, OH 44106 USA Case Western Reserve Univ, Div Cardiol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Dept Med, Div Clin Pharmacol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Dept Pharmacol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 6, volume: 280, anno: 2001,
pagine: H2770 - H2778
SICI:
0363-6135(200106)280:6<H2770:MISDCI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOCHROME-C-OXIDASE; NONESTERIFIED FATTY-ACIDS; OXIDATIVE-PHOSPHORYLATION; COLUMN CHROMATOGRAPHY; MECHANICAL RECOVERY; ADENINE-NUCLEOTIDE; BOUND CARDIOLIPIN; RESPIRATORY-CHAIN; SILICA-GEL; RAT-HEART;
Keywords:
cytochrome oxidase; phospholipids; electron transport chain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Lesnefsky, EJ Louis Stokes VA Med Ctr, Cardiol Sect, Med Serv 111W, 10701 East Blvd, Cleveland, OH 44106 USA Louis Stokes VA Med Ctr 10701 East Blvd Cleveland OH USA 44106
Citazione:
E.J. Lesnefsky et al., "Myocardial ischemia selectively depletes cardiolipin in rabbit heart subsarcolemmal mitochondria", AM J P-HEAR, 280(6), 2001, pp. H2770-H2778

Abstract

Mitochondria contribute to myocyte injury during ischemia. After 30 and 45min of ischemia in the isolated perfused rabbit heart, subsarcolemmal mitochondria (SSM), located beneath the plasma membrane, sustain a decrease in oxidative phosphorylation through cytochrome oxidase. In contrast, oxidation through cytochrome oxidase in interfibrillar mitochondria (IFM), located between the myofibrils, remains unaffected. Cytochrome oxidase activity in the intact membrane requires an inner mitochondrial membrane lipid environment enriched in cardiolipin. During ischemia, the content of cardiolipin decreased only in SSM, whereas the content of other phospholipids was preserved. Ischemia did not alter the composition of the cardiolipin that remainedin SSM. Cardiolipin content was preserved in IFM during ischemia. Thus cardiolipin is a relatively early target of ischemic mitochondrial damage, leading to loss of oxidative phosphorylation through cytochrome oxidase in SSM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:48:01