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Titolo:
Oxygen delivery at high blood viscosity and decreased arterial oxygen content to brains of conscious rats
Autore:
Rebel, A; Lenz, C; Krieter, H; Waschke, KF; Van Ackern, K; Kuschinsky, W;
Indirizzi:
Fac Clin Med, Dept Anesthesiol, D-68067 Mannheim, Germany Fac Clin Med Mannheim Germany D-68067 thesiol, D-68067 Mannheim, Germany Univ Heidelberg, Dept Physiol, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 6, volume: 280, anno: 2001,
pagine: H2591 - H2597
SICI:
0363-6135(200106)280:6<H2591:ODAHBV>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISOVOLEMIC HEMODILUTION; CARBON-MONOXIDE; FLOW; LAMB;
Keywords:
anemia; cerebral blood flow; autoradiography blood replacement; microcirculation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Rebel, A Johns Hopkins Univ, Sch Med, Dept Anesthesiol Crit Care Med, 600 N Wolfe St,Blalock 1404, Baltimore, MD 21287 USA Johns Hopkins Univ 600 N Wolfe St,Blalock 1404 Baltimore MD USA 21287
Citazione:
A. Rebel et al., "Oxygen delivery at high blood viscosity and decreased arterial oxygen content to brains of conscious rats", AM J P-HEAR, 280(6), 2001, pp. H2591-H2597

Abstract

We addressed the question to which extent cerebral blood flow (CBF) is maintained when, in addition to a high blood viscosity (B-vis) arterial oxygencontent (Ca-O2) is gradually decreased. Ca-O2 was decreased by hemodilution to hematocrits (Hct) of 30, 22, 19, and 15% in two groups. One group received blood replacement (BR) only and served as the control. The second group received an additional high viscosity solution of polyvinylpyrrolidone (BR/PVP). B-vis was reduced in the BR group and was doubled in the BR/PVP. Despite different B-vis, CBF did not differ between BR and BR/PVP rats at Hctvalues of 30 and 22%, indicating a complete vascular compensation of the increased B-vis at decreased Ca-O2. At an Hct of 19%, local cerebral blood flow (LCBF) in some brain structures was lower in BR/PVP rats than in BR rats. At the lowest Hct of 15%, LCBF of 15 brain structures and mean CBF were reduced in BR/PVP. The resulting decrease in cerebral oxygen delivery in the BR/PVP group indicates a global loss of vascular compensation. We concluded that vasodilating mechanisms compensated for Bvis increases thereby maintaining constant cerebral oxygen delivery. Compensatory mechanisms were exhausted at a Hct of 19% and lower as indicated by the reduction of CBF and cerebral oxygen delivery.

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Documento generato il 25/01/20 alle ore 16:46:38