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Titolo:
Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents
Autore:
Braun, RD; Lanzen, JL; Snyder, SA; Dewhirst, MW;
Indirizzi:
Duke Univ, Med Ctr, Dept Radiat Oncol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 tr, Dept Radiat Oncol, Durham, NC 27710 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 6, volume: 280, anno: 2001,
pagine: H2533 - H2544
SICI:
0363-6135(200106)280:6<H2533:COTANT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMA; PREDICTS RADIATION RESPONSE; UTERINE CERVIX; HYPERBARIC-OXYGEN; RECESSED CATHODE; PO(2) GRADIENTS; ADVANCED CANCER; WINDOW CHAMBER; SOLID TUMORS; HYPOXIA;
Keywords:
polarographic microelectrode; luminescence fiber-optic sensor; tumor hypoxia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Dewhirst, MW Duke Univ, Med Ctr, Dept Radiat Oncol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 at Oncol, Durham, NC 27710 USA
Citazione:
R.D. Braun et al., "Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents", AM J P-HEAR, 280(6), 2001, pp. H2533-H2544

Abstract

In this study we compare oxygen tension (PO2) histograms measured with O-2microelectrodes and a new optical PO2 measurement device, the OxyLite, in normal tissues (mouse spleen and thymus) and in tumors (R3230Ac in rats) (n= 5-6). The transient response to glucose infusion or 100% O-2 breathing (hyperoxia) was also measured in tumors. PO2 histograms of spleen and thymuswith the two devices were not different. The OxyLite tumor PO2 histogram, however, was left-shifted compared with the microelectrode (median PO2 1.0 vs. 4.0 mmHg, P = 0.016). Both probes responded to acute hyperglycemia witha mean increase of 3-6 mmHg, but the microelectrode change was not significant. The OxyLite consistently recorded large PO2 increases (similar to 28 mmHg) with hyperoxia, whereas the microelectrode response was variable. TheOxyLite averages PO2 over an area that contains interstitial and vascular components, whereas the microelectrode measures a more local PO2. This study demonstrates the importance of considering the features of the measurement device when studying tissues with heterogeneous PO2 distributions (e.g., tumors).

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Documento generato il 14/07/20 alle ore 03:43:19