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Titolo:
Arterial baroreflex control of sympathetic nerve activity during acute hypotension: effect of fitness
Autore:
Fadel, PJ; Stromstad, M; Hansen, J; Sander, M; Horn, K; Ogoh, S; Smith, ML; Secher, NH; Raven, PB;
Indirizzi:
Univ N Texas, Dept Integrat Physiol, Ft Worth, TX 76107 USA Univ N Texas Ft Worth TX USA 76107 tegrat Physiol, Ft Worth, TX 76107 USA Univ N Texas, Inst Cardiovasc Res, Ft Worth, TX 76107 USA Univ N Texas FtWorth TX USA 76107 Cardiovasc Res, Ft Worth, TX 76107 USA Univ Copenhagen, Rigshosp, Dept Anesthesia, Copenhagen Muscle Res Ctr, DK-2200 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-2200 , DK-2200 Copenhagen, Denmark
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 6, volume: 280, anno: 2001,
pagine: H2524 - H2532
SICI:
0363-6135(200106)280:6<H2524:ABCOSN>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE REGULATION; BODY NEGATIVE-PRESSURE; AORTIC-CARDIAC REFLEX; HEART-RATE; ORTHOSTATIC INTOLERANCE; CAROTID BAROREFLEX; EXERCISE; HUMANS; TOLERANCE; MEN;
Keywords:
carotid baroreceptors; aortic baroreceptors; endurance training; neck suction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Fadel, PJ Univ Texas, SW Med Ctr, Div Hypertens, 5323 Harry Hines Blvd, Dallas, TX 75390 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75390 X 75390 USA
Citazione:
P.J. Fadel et al., "Arterial baroreflex control of sympathetic nerve activity during acute hypotension: effect of fitness", AM J P-HEAR, 280(6), 2001, pp. H2524-H2532

Abstract

We examined arterial baroreflex control of muscle sympathetic nerve activity (MSNA) during abrupt decreases in mean arterial pressure (MAP) and evaluated whether endurance training alters baroreflex function. Acute hypotension was induced nonpharmacologically in 14 healthy subjects, of which 7 wereof high fitness (HF) and 7 were of average fitness (AF), by releasing a unilateral arterial thigh cuff after 9 min of resting ischemia under two conditions: control, which used aortic and carotid baroreflex (ABR and CBR, respectively) deactivation; and suction, which used ABR deactivation alone. The application of neck suction to counteract changes in carotid sinus transmural pressure during cuff release significantly attenuated the MSNA response (which increased 134 +/- 32 U/14 s) compared with control (which increased 195 +/- 43 U/14 s) and caused a greater decrease in MAP (19 +/- 2 vs. 15 /- 2 mmHg; P< 0.05). Furthermore, during both trials, the HF subjects exhibited a greater decrease in MAP compared with AF subjects despite an augmented baroreflex control of MSNA. These data indicate that the CBR contributes importantly to the MSNA response during acute systemic hypotension. Additionally, we suggest that an impaired control of vascular reactivity hindersblood pressure regulation in HF subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 09:12:08