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Titolo:
Gender-specific compensation for the lack of NO in the mediation of flow-induced arteriolar dilation
Autore:
Wu, YM; Huang, A; Sun, D; Falck, JR; Koller, A; Kaley, G;
Indirizzi:
New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA New York Med CollValhalla NY USA 10595 t Physiol, Valhalla, NY 10595 USA Univ Texas, SW Med Ctr, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 iv Texas, SW Med Ctr, Dallas, TX 75235 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 6, volume: 280, anno: 2001,
pagine: H2456 - H2461
SICI:
0363-6135(200106)280:6<H2456:GCFTLO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; HYPERPOLARIZING FACTOR; ARACHIDONIC-ACID; CONSCIOUS DOGS; KNOCKOUT MICE; CORONARY; INHIBITION; CYCLOOXYGENASE; PROSTAGLANDINS; RELEASE;
Keywords:
NO synthesis; hyperpolarizing factor; cytochrome P-450 metabolites; potassium channels;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Kaley, G New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA New York Med Coll Valhalla NY USA 10595 , Valhalla, NY 10595 USA
Citazione:
Y.M. Wu et al., "Gender-specific compensation for the lack of NO in the mediation of flow-induced arteriolar dilation", AM J P-HEAR, 280(6), 2001, pp. H2456-H2461

Abstract

Flow-induced dilation of gracilis muscle arterioles was examined in both genders of control rats and rats chronically treated with N-omega-nitro-L-arginine methyl ester (L-NAME). After L-NAME treatment (4 wk), systolic bloodpressure was significantly increased compared with control, whereas the plasma concentration of nitrate/nitrite was significantly reduced. Isolated and pressurized arterioles dilated significantly in response to increases inflow (0-25 mul/ min). Flow-induced dilation was comparable in arterioles of control and L-NAME-treated rats but was significantly greater in female than in male rats. L-NAME + indomethacin, which abolished flow- induced dilation in arterioles of male control rats, inhibited the dilation by only similar to 75% in female control rats. The residual portion of the response was eliminated by additional administration of miconazole, an inhibitor of cytochrome P-450. Indomethacin did not affect the dilation in female L-NAME- treated rats but completely inhibited the response in male L-NAME-treated rats. The indomethacin-insensitive, flow-induced dilation in female L-NAME-treated arterioles was abolished by miconazole, 6-( 2-proparglyoxyphenyl) hexanoic acid, or charybdotoxin. Thus an augmented release of endothelial prostaglandins accounts for the preserved flow-induced dilation in arterioles of male rats, whereas a metabolite of cytochrome P-450 is responsible for the maintenance of flow-induced dilation in female rats, suggesting important differences in the adaptation of the endothelium of arterioles from male and female rats to the lack of nitric oxide (NO) synthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:51:49