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Titolo:
Nicotine infusion alters leptin and uncoupling protein 1 mRNA expression in adipose tissues of rats
Autore:
Arai, K; Kim, K; Kaneko, K; Iketani, M; Otagiri, A; Yamauchi, N; Shibasaki, T;
Indirizzi:
Nippon Med Sch, Dept Physiol, Bunkyo Ku, Tokyo 1138602, Japan Nippon Med Sch Tokyo Japan 1138602 siol, Bunkyo Ku, Tokyo 1138602, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
fascicolo: 6, volume: 280, anno: 2001,
pagine: E867 - E876
SICI:
0193-1849(200106)280:6<E867:NIALAU>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RIBONUCLEIC-ACID; OBESE GENE-EXPRESSION; BODY-WEIGHT; PARAVENTRICULAR NUCLEUS; CIGARETTE-SMOKING; ENERGY-BALANCE; NEUROPEPTIDE-Y; RNA EXPRESSION; OB/OB MICE; INSULIN;
Keywords:
food intake; body weight; energy balance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Arai, K Nippon Med Sch, Dept Physiol, Bunkyo Ku, 1-1-5 Sendagi, Tokyo 1138602, Japan Nippon Med Sch 1-1-5 Sendagi Tokyo Japan 1138602 o 1138602, Japan
Citazione:
K. Arai et al., "Nicotine infusion alters leptin and uncoupling protein 1 mRNA expression in adipose tissues of rats", AM J P-ENDO, 280(6), 2001, pp. E867-E876

Abstract

We attempted to clarify whether leptin and uncoupling protein 1 (UCP1) areinvolved in the action of nicotine on the energy balance. Male Wistar ratswere infused subcutaneously with nicotine (12 mg.kg(-1).day(-1)) for 4 or 14 days. At the end of the 4-day period, the plasma concentrations of leptin of the nicotine-treated and pair-fed rats were lower than those of the freely fed rats, although the levels of leptin mRNA expression in various white adipose tissues did not differ among the three groups. At the end of the14-day nicotine infusion period, plasma concentrations of leptin were higher, and leptin mRNA expression in the omentum and epididymal and retroperitoneal adipose tissues was stronger in the nicotine-treated rats than in thepair-fed and freely fed rats. UCP1 mRNA expression in the brown adipose tissue of nicotine-treated was stronger than that of the pair-fed rats. Theseresults suggest that continuous nicotine infusion differentially affects the synthesis and secretion of leptin according to the duration of infusion and stimulates UCP1 mRNA expression, probably in a manner independent of leptin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 01:19:02