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Titolo:
Neonatal-perinatal risk factors for the development of persistent pulmonary hypertension of the newborn in preterm newborns
Autore:
Muraskas, JK; Juretschke, LJ; Weiss, MG; Bhola, M; Besinger, RE;
Indirizzi:
Loyola Univ, Med Ctr, Ronald McDonald Childrens Hosp, Div Neonatol, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 osp, Div Neonatol, Maywood, IL 60153 USA Loyola Univ, Med Ctr, Ronald McDonald Childrens Hosp, Dept Nursing, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 osp, Dept Nursing, Maywood, IL 60153 USA Loyola Univ, Med Ctr, Div Maternal Fetal Med, Maywood, IL 60153 USA LoyolaUniv Maywood IL USA 60153 aternal Fetal Med, Maywood, IL 60153 USA
Titolo Testata:
AMERICAN JOURNAL OF PERINATOLOGY
fascicolo: 2, volume: 18, anno: 2001,
pagine: 87 - 91
SICI:
0735-1631(2001)18:2<87:NRFFTD>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; INFANTS; MEMBRANES; RUPTURE; PROSTACYCLIN; MANAGEMENT; DISEASE;
Keywords:
persistent pulmonary hypertension of the newborn; pulmonary vascular resistance; antenatal steroids; prolonged premature rupture of the membranes; maternal tobacco use;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Muraskas, JK Loyola Univ, Med Ctr, Ronald McDonald Childrens Hosp, Div Neonatol, 2160 S1st Ave, Maywood, IL 60153 USA Loyola Univ 2160 S 1st Ave Maywood IL USA 60153 IL 60153 USA
Citazione:
J.K. Muraskas et al., "Neonatal-perinatal risk factors for the development of persistent pulmonary hypertension of the newborn in preterm newborns", AM J PERIN, 18(2), 2001, pp. 87-91

Abstract

There is a long-held belief that preterm newborns lack sufficient arteriolar musculature to maintain a prolonged elevated pulmonary vascular resistance (PVR) after birth. Net ductal flow is thought to be minimal, with the developing pulmonary circulation incapable of significant vasoconstriction. We identified retrospectively 15 premature newborns over a 10-year period weighing less than or equal to 1500 g and with a gestational age of less thanor equal to 30 weeks with documented persistent pulmonary hypertension of the newborn (PPHN) in the first 24 hours after birth. We matched 36 newborns of similar weight and gestation with no clinical evidence of shunting. The control group weaned to an FiO(2) less than or equal to 0.50 by 12 hours after birth. Despite similar gestational ages, the PPHN group (n = 15) had significantly higher birth weights than the control group (n = 36). The duration of ruptured membranes, maternal tobacco use, and use of antenatal steroids were significantly higher in the PPHN group. We speculate that these three factors might act in a synergistic relationship with which to accelerate pulmonary vascular smooth muscle development in premature newborns.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 16:48:59