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Titolo:
Statins - Similarities and differences
Autore:
Pedersen, T; Gaw, A;
Indirizzi:
Univ Oslo, Aker Hosp, Dept Cardiol, Oslo, Norway Univ Oslo Oslo NorwayUniv Oslo, Aker Hosp, Dept Cardiol, Oslo, Norway Glasgow Royal Infirm, Clin Trials Unit, Glasgow G4 0SF, Lanark, Scotland Glasgow Royal Infirm Glasgow Lanark Scotland G4 0SF 0SF, Lanark, Scotland
Titolo Testata:
AMERICAN JOURNAL OF MANAGED CARE
fascicolo: 5, volume: 7, anno: 2001, supplemento:, S
pagine: S132 - S137
SICI:
1088-0224(200105)7:5<S132:S-SAD>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; AVERAGE CHOLESTEROL LEVELS; COA REDUCTASE INHIBITORS; PRAVASTATIN; PREVENTION; EVENTS; HYPERCHOLESTEROLEMIA; ATORVASTATIN; SIMVASTATIN; LOVASTATIN;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Pedersen, T Univ Oslo, Aker Hosp, Dept Cardiol, Oslo, Norway Univ Oslo Oslo Norway Aker Hosp, Dept Cardiol, Oslo, Norway
Citazione:
T. Pedersen e A. Gaw, "Statins - Similarities and differences", AM J M CARE, 7(5), 2001, pp. S132-S137

Abstract

The number of statins available to physicians continues to grow, leading to the question: Are all statins alike? Comparisons of side effects and safety profiles and the dose-response relationship among the different drugs show similar results. The cholesterol-lowering action of each depends on its ability to lower low-density lipoprotein cholesterol (LDL-C). On the other hand, the molecular structures of the newer statins are not similar and could have an effect on the mechanism of action of the compounds. Differences in metabolism also suggest the possibility of serious drug-drug interactions, and differences in levels of lipid reduction at varying dosages among the statins point to clinical variation as well.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 20:08:51