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Titolo:
Pioglitazone, a specific PPAR-gamma ligand, inhibits aspirin-induced gastric mucosal injury in rats
Autore:
Naito, Y; Takagi, T; Matsuyama, K; Yoshida, N; Yoshikawa, T;
Indirizzi:
Kyoto Prefectural Univ Med, Dept Med 1, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 Ku, Kyoto 6028566, Japan
Titolo Testata:
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
fascicolo: 6, volume: 15, anno: 2001,
pagine: 865 - 873
SICI:
0269-2813(200106)15:6<865:PASPLI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; PROLIFERATOR-ACTIVATED RECEPTORS; WISTAR FATTY RATS; LEUKOCYTE ADHESION; MESENTERIC VENULES; OXYGEN RADICALS; INDOMETHACIN; EXPRESSION; PATHWAY; INFLAMMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Naito, Y Kyoto Prefectural Univ Med, Dept Med 1, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 o 6028566, Japan
Citazione:
Y. Naito et al., "Pioglitazone, a specific PPAR-gamma ligand, inhibits aspirin-induced gastric mucosal injury in rats", ALIM PHARM, 15(6), 2001, pp. 865-873

Abstract

Background: Neutrophils activation and tumour necrosis factor-alpha (TNF-alpha) induction play a critical role in aspirin-induced gastric mucosal injury. Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), a member of the nuclear hormone receptor superfamily, has recently been implicatedas a regulator of inflammatory responses. The aim of the present study wasto determine whether pioglitazone, a specific PPAR-gamma ligand, can ameliorate aspirin-induced gastric mucosal injury in rats, and whether the agentcan inhibit the increase in neutrophil accumulation associated with TNF-alpha expression. Methods: Aspirin-induced injury was produced by the intragastric administration of aspirin (200 mg/kg) and HCl (0.15 N, 8.0 mL/kg). Pioglitazone was given to the rats by gastric intubation 1 h before the aspirin administration. Thiobarbituric acid-reactive substances and tissue-associated myeloperoxidase activity were measured in gastric mucosa as indices of lipid peroxidation and neutrophil infiltration. The gastric concentration of TNF-alpha and the expression of TNF-alpha mRNA was determined by ELISA and reverse transcriptase-polymerase chain reaction. Results: The intragastric administration of acidified aspirin induced hyperemia and haemorrhagic erosions in rat stomachs. The increase in the total gastric erosive area after aspirin administration was significantly inhibited by treatment with pioglitazone in a dose-dependent manner. The increasesin thiobarbituric acid-reactive substances and myeloperoxidase activity after aspirin administration were both significantly inhibited by pre-treatment with pioglitazone (10 mg/kg). The gastric content of TNF-alpha increasedand the expression of TNF-alpha mRNA was up-regulated after aspirin treatment. However, the peak TNF-alpha mRNA expression 1 h after aspirin administration was inhibited by pioglitazone. Conclusion: Based on these data, the beneficial effects of pioglitazone onaspirin-induced gastric mucosal injury may be attributed to its anti-inflammatory properties.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:40:50