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Titolo:
Free-choice alcohol consumption in mice after application of the appetite regulating peptide leptin
Autore:
Kiefer, F; Jahn, H; Wolf, K; Kampf, P; Knaudt, K; Wiedemann, K;
Indirizzi:
Univ Hamburg, Hosp Eppendorf, Dept Psychiat & Psychotherapy, D-20246 Hamburg, Germany Univ Hamburg Hamburg Germany D-20246 hotherapy, D-20246 Hamburg, Germany
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 5, volume: 25, anno: 2001,
pagine: 787 - 789
SICI:
0145-6008(200105)25:5<787:FACIMA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROOPIOMELANOCORTIN MESSENGER-RNA; BODY-WEIGHT REGULATION; PLASMA LEPTIN; FOOD-INTAKE; OBESE GENE; PROTEIN; OB/OB;
Keywords:
leptin; alcoholism craving; addiction; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Kiefer, F Univ Hamburg, Hosp Eppendorf, Dept Psychiat & Psychotherapy, Martinistr 52, D-20246 Hamburg, Germany Univ Hamburg Martinistr 52 Hamburg Germany D-20246 urg, Germany
Citazione:
F. Kiefer et al., "Free-choice alcohol consumption in mice after application of the appetite regulating peptide leptin", ALC CLIN EX, 25(5), 2001, pp. 787-789

Abstract

Background: Leptin has been shown to regulate food intake and energy expenditure. Very recently, associations of elevated leptin plasma levels duringalcohol withdrawal with alcohol craving have been observed in humans. Therefore, we tested the hypothesis that the application of exogenous leptin modulates voluntary alcohol consumption in mice. Methods: Sixteen mice (129/Sv x C57BL/6J) were habituated to ethanol consumption over a time period of 3 months. After a basal 2-week free-choice drinking phase, mice were separated into two groups (n = 8) according to weight and alcohol consumption. They received recombinant leptin (1 mg/kg) versus saline intraperitoneally daily for 10 days. After 4 days of free-choice consumption of ethanol (16% v/v) versus water, ethanol was withdrawn at day 4 and replaced at day 6 to test the occurrence of an alcohol deprivation effects. Fluid intake was evaluated by controlling the weight of the drinkingtubes daily. Results: Free-choice ethanol consumption after withdrawal was significantly elevated in mice after intraperitoneal injection of 1 mg/kg leptin (alcohol deprivation effect), but not during basal drinking. Conclusion: We suggest that leptin may enhance motivation for alcohol consumption in habituated mice after alcohol withdrawal.

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Documento generato il 19/01/20 alle ore 09:07:01