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Titolo:
The combined dexamethasone-suppression/CRH-stimulation test in alcoholics during and after acute withdrawal
Autore:
Hundt, W; Zimmermann, U; Pottig, M; Spring, K; Holsboer, F;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 5, volume: 25, anno: 2001,
pagine: 687 - 691
SICI:
0145-6008(200105)25:5<687:TCDTIA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; CORTICOTROPIN-RELEASING HORMONE; MDR1A P-GLYCOPROTEIN; CRH TEST; ETHANOL WITHDRAWAL; DEPRESSED-PATIENTS; TERM ABSTINENCE; CORTISOL; ACTH; DISORDERS;
Keywords:
alcoholism; withdrawal; cortisol; ACTH; Dex/CRH test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Zimmermann, U Max Planck Inst Psychiat, Kraepelinstr 10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 10 Munich Germany D-80804
Citazione:
W. Hundt et al., "The combined dexamethasone-suppression/CRH-stimulation test in alcoholics during and after acute withdrawal", ALC CLIN EX, 25(5), 2001, pp. 687-691

Abstract

Background: Chronic alcoholism is often accompanied by disturbances of thehypothalamic-pituitary-adrenal (PIPA) system. Patients with alcoholism frequently show nonsuppression in the dexamethasone (Dex) suppression test andalso a blunted increase of adrenocorticotropin (ACTH) after injection of corticotropin-releasing hormone (hCRH). However, the underlying mechanisms have not been fully elucidated. The combined Dex/CRH test (pretreatment with1.5 mg dexamethasone at 2300 hr, injection of 100 mug hCRH at 1500 hr the next day) has been established as a more sensitive tool to investigate HPA system regulation in depressed patients. Methods: We studied the effect of the combined Dex/CRH test in 19 alcoholic inpatients (9 male, 10 female) during and after withdrawal along with 19 healthy controls. Results: Compared to normal controls, patients showed a severely dysregulated HPA system during withdrawal, with significantly elevated cortisol and ACTH response to hCRH after pretreatment with dexamethasone. After completed withdrawal, cortisol levels after injection of hCRH were almost normalized while ACTH values were partially lower in patients, compared to controls. Conclusions: We conclude that the HPA system is severely disturbed during alcohol withdrawal, possibly reflecting an exaggerated release of hypothalamic corticotropin and vasopressin.

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Documento generato il 19/01/20 alle ore 01:05:14