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Titolo:
Residual human immunodeficiency virus type 1 infection in lymphoid tissue during highly active antiretroviral therapy: Quantitation and virus characterization
Autore:
Dyrhol-Riise, AM; Voltersvik, P; Berg, OG; Olofsson, J; Kleivbo, S; Asjo, B;
Indirizzi:
Univ Bergen, Ctr Res Virol, Gade Inst, Dept Microbiol & Immunol, N-5020 Bergen, Norway Univ Bergen Bergen Norway N-5020 robiol & Immunol, N-5020 Bergen, Norway Haukeland Univ Hosp, Dept Otolaryngol Head & Neck Surg, N-5021 Bergen, Norway Haukeland Univ Hosp Bergen Norway N-5021 eck Surg, N-5021 Bergen, Norway
Titolo Testata:
AIDS RESEARCH AND HUMAN RETROVIRUSES
fascicolo: 7, volume: 17, anno: 2001,
pagine: 577 - 586
SICI:
0889-2229(20010501)17:7<577:RHIVT1>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD4(+) T-CELLS; HIV-1 INFECTION; PROTEASE INHIBITOR; REVERSE-TRANSCRIPTASE; COMBINATION THERAPY; TONSILLAR TISSUE; PERIPHERAL-BLOOD; VIRAL LOAD; IN-VIVO; PLASMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Dyrhol-Riise, AM HIB, Ctr Res Virol, N-5020 Bergen, Norway HIB Bergen Norway N-5020 s Virol, N-5020 Bergen, Norway
Citazione:
A.M. Dyrhol-Riise et al., "Residual human immunodeficiency virus type 1 infection in lymphoid tissue during highly active antiretroviral therapy: Quantitation and virus characterization", AIDS RES H, 17(7), 2001, pp. 577-586

Abstract

HIV-1 can persist in infected patients despite undetectable plasma viremia, To characterize the residual viral load, repetitive blood and tonsillar samples were collected from 11 HIV-1-positive individuals before and during 96 weeks of therapy with zidovudine, lamivudine, and indinavir, HIV-1 RNA in tonsils was quantified by RT-PCR and infectious HIV-1 provirus by the limiting dilution assay. Genotypic resistance analyses and biological characterization were performed on plasma virus, blood, and tonsillar isolates. Tonsillar infectious HIV-1 provirus and HIV-1 RNA declined by 2 and 3 log(10),respectively, but 10(3)-10(4) cells, less than 0.5% of the total body CD4() T cell population carrying infectious HIV-1 provirus, remained involved in active viral replication of drug-sensitive R5 viruses. Thus, the dominant HIV-1 residual infection consists of less than or equal to 10(6) latentlyinfected CD4(+) cells. Plasma HIV-1 RNA decline of >1.5 log(10) during thefirst 2 weeks of therapy may indicate low levels of this latent reservoir. Whereas the reservoir of latently infected cells remains stable, actively replicating HIV-1 continuously declines during prolonged antiretroviral therapy. Thus, although viral eradication seems unlikely, antiretroviral therapy may induce an extended period of virologic latency in HIV-1-positive individuals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 18:54:50