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Titolo:
Leptin: a parameter of metabolic changes in congestive heart failure
Autore:
Richartz, BM; Lotze, U; Krack, A; Gastmann, A; Kuthe, F; Figulla, HR;
Indirizzi:
Univ Jena, Innere Med Klin 3, D-07740 Jena, Germany Univ Jena Jena Germany D-07740 Innere Med Klin 3, D-07740 Jena, Germany
Titolo Testata:
ZEITSCHRIFT FUR KARDIOLOGIE
fascicolo: 4, volume: 90, anno: 2001,
pagine: 280 - 285
SICI:
0300-5860(200104)90:4<280:LAPOMC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
GER
Soggetto:
TUMOR-NECROSIS-FACTOR; BROWN ADIPOSE-TISSUE; CARDIAC CACHEXIA; ENERGY-EXPENDITURE; FACTOR-ALPHA; OBESE GENE; INSULIN; RECEPTORS; CYTOKINES; WEIGHT;
Keywords:
leptin; congestive heart failure; metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Richartz, BM Univ Jena, Innere Med Klin 3, Erlanger Allee 101, D-07740 Jena, Germany Univ Jena Erlanger Allee 101 Jena Germany D-07740 a, Germany
Citazione:
B.M. Richartz et al., "Leptin: a parameter of metabolic changes in congestive heart failure", Z KARDIOL, 90(4), 2001, pp. 280-285

Abstract

Objective Advanced chronic heart failure is a hypercatabolic state with animbalance between anabolic and catabolic metabolism and finally progressive loss of both muscle mass and adipose tissue. Leptin, the product of the obesity gene, is a hormone secreted by adipocytes. Therfore, we tested the hypothesis that plasma leptin concentrations are reduced in advanced chronicheart failure. Methods In 20 patients with chronic congestive heart failure (LVEF 23 +/- 6%) and 20 healthy controls (LVEF 65 +/- 8%) matched for gender, age, and body mass index, fasting plasma leptin (ELISA) and TNF alpha (ELISA) were measured. Follow-up examination was performed after 1 year. Results The fasting plasma leptin concentrations of patients with NYHA grade III(8.4+/-3.8 ng/ml*) and NYHA grade IV (4.6 +/- 2.4 ng/ml dagger) were significantly lower as compared with the controls (11.2+/-3.1 ng/ml; * p < 0.05, <dagger> p < 0.01). In patients with NYHA grade II plasma leptin levels were significantly elevated as compared with the healthy controls (14.9 +/-4.2 ng/ mi). TNF<alpha>. was higher in heart failure patients than in healthy controls (8.6 +/- 3.6 pg/ml; 5.9 +/- 2.1 pg/ml; respectively; p<0.05), but did not correlate with the NYHA functional class. Mortality of the controls was 0%, whereas 15% (n=3) in the congestive heart failure group; one patient (5%) needs an urgent heart transplantation. All of those patients had leptin concentrations below 5 ng/ mi. Conclusions Plasma leptin concentrations correlate with the NYHA functional class suggesting anabolic metabolism in NYHA class II and catabolic metabolism in advanced heart failure which might be of prognostic relevance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:24:10