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Titolo:
Polyvinyl pyrrolidone-iodine liposome hydrogel improves epithelialization by combining moisture and antisepsis. A new concept in wound therapy
Autore:
Vogt, PM; Hauser, J; Rossbach, O; Bosse, B; Fleischer, W; Steinau, HU; Reimer, K;
Indirizzi:
Ruhr Univ Bochum, Univ Klin, BG Klinikum Bergmannsheil,Dept Plast Surg, Univ Klin Plast Chirurg & Schwerbrandverletzte, D-44702 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-44702 rletzte, D-44702 Bochum, Germany Mundipharma GmbH, Limburg, Germany Mundipharma GmbH Limburg GermanyMundipharma GmbH, Limburg, Germany
Titolo Testata:
WOUND REPAIR AND REGENERATION
fascicolo: 2, volume: 9, anno: 2001,
pagine: 116 - 122
SICI:
1067-1927(200103/04)9:2<116:PPLHIE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
POVIDONE-IODINE; RELEVANT MICROORGANISMS; FIBRONECTIN; REPAIR; DRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Vogt, PM Ruhr Univ Bochum, Univ Klin, BG Klinikum Bergmannsheil,Dept PlastSurg, Univ Klin Plast Chirurg & Schwerbrandverletzte, D-44702 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-44702 D-44702 Bochum, Germany
Citazione:
P.M. Vogt et al., "Polyvinyl pyrrolidone-iodine liposome hydrogel improves epithelialization by combining moisture and antisepsis. A new concept in wound therapy", WOUND R REG, 9(2), 2001, pp. 116-122

Abstract

Moist treatment of wounds has been shown to improve epithelialization. however at an increased risk of bacterial infection. In this monocentric, randomized, open, phase II pilot study of polyvinyl pyrrolidone-iodine, a well-established topical antiseptic was tested in a new liposomal complexed formin patients receiving meshed skin grafts after burns or reconstructive procedures. Mesh skin graft sites of 36 patients were dressed either with the new polyvinyl-pyrrolidone-iodine liposome hydrogel formulation (Betasom hydrogel) (n = 21). or chlorhexidine-gauze (n = 15). After the first dressing change, wounds were assessed daily and documented every other day until they were healed. Methods of analysis included clinical assessment, photoplanimetry (rate of epithelialization), impedance measurement (moisture of surface and wound healing quality), patient's assessment of pain and other sensations, and thyroid hormones (T-3, T-4, and TSH). The rate of epithelialization was improved with Betasom hydrogel compared to chlorhexidine-gauze on day 11 (96.3% vs. 75.9% p = 0.056) and significantly on day 13 (100% vs. 82.3% p = 0.005), respectively. Impedance measurements showed an earlier return to normal values (day 9) in Betasom-hydrogel-treated wounds as opposed tochlorhexidine treatment (day 11). Clinical assessment indicated significantly better antiseptic efficacy (p = 0.002) and wound healing quality (p = 0.004) of Betasom hydrogel. Graft loss occurred at a significantly lower rate in Betasom treatment (n = 1: 5%), than in chlorhexidine treatment (n = 5:35.7%) (p = 0.001). No relevant adverse events or clinically relevant changes of thyroid hormones were observed with Betasom hydrogel. The rationale of this new polyvinyl pyrrolidone-iodine liposomal formulation was based onthe properties of liposomes that provide higher moisture to the wound surface, release PVP-iodine at a low rate, and target the substance more exactly by interaction with the cell surface. These initial clinical results showearlier epithelialization and better healing in wounds treated with polyvinyl pyrrolidone-iodine liposome hydrogel, which combines moisture and antisepsis, compared to wounds treated with a conventional antiseptic chlorhexidine-gauze.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:16:10