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Titolo:
Organization of the inner retina following early elimination of the retinal ganglion cell population: Effects on cell numbers and stratification patterns
Autore:
Williams, RR; Cusato, K; Raven, MA; Reese, BE;
Indirizzi:
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USA Univ Calif Santa Barbara Santa Barbara CA USA 93106 Barbara, CA 93106 USA Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA Univ Calif Santa Barbara Santa Barbara CA USA 93106 Barbara, CA 93106 USA
Titolo Testata:
VISUAL NEUROSCIENCE
fascicolo: 2, volume: 18, anno: 2001,
pagine: 233 - 244
SICI:
0952-5238(200103/04)18:2<233:OOTIRF>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLINERGIC AMACRINE CELLS; ROD BIPOLAR CELLS; GABA-LIKE IMMUNOREACTIVITY; C-LIKE IMMUNOREACTIVITY; MACAQUE MONKEY RETINA; DEVELOPING RAT RETINA; RABBIT RETINA; CAT RETINA; SYNAPTIC ORGANIZATION; TYROSINE-HYDROXYLASE;
Keywords:
inner plexiform layer; amacrine cell; optic nerve; axotomy; cell death;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
97
Recensione:
Indirizzi per estratti:
Indirizzo: Reese, BE Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USA Univ Calif Santa Barbara Santa Barbara CA USA 93106 A 93106 USA
Citazione:
R.R. Williams et al., "Organization of the inner retina following early elimination of the retinal ganglion cell population: Effects on cell numbers and stratification patterns", VIS NEUROSC, 18(2), 2001, pp. 233-244

Abstract

The present study has examined the effects of early ganglion cell elimination upon the organization of the inner retina in the fel ret. The population of retinal ganglion cells was removed by optic nerve transection on the second postnatal day, and retinas were subsequently studied in adulthood. Numbers of amacrine and bipolar cells were compared in the nerve-transected and nerve-intact retinas of operated ferrets, while stratification patterns within the inner plexiform layer were compared in these and in normal ferret retinas. Early ganglion cell elimination was found to produce a 25% reduction in the population of glycine transporter-immunoreactive amacrine cells, and LX and 15% reductions in the populations of parvalbumin and calbindin-immunoreactive amacrine cells, respectively. GABAergic amacrine cells werealso reduced by 34%. The number of calbindin-immunoreactive displaced amacrine cells, by contrast, had increased in the ganglion cell-depleted retina, bring three times their normal number. Other amacrine and bipolar cell types were unaffected. Despite these changes, the stratification patterns associated with these cell types remained largely intact within the inner plexiform layer. The present results demonstrate a class-specific dependency ofinner retinal neurons upon the ganglion cell population in early postnatallife, but the ganglion cells do not appear to provide any critical signalsfor stratification within the inner plexiform layer, at least not after birth. Since they themselves do not produce stratified dendritic arbors untilwell after birth, the signals for stratification of the bipolar and amacrine cell processes should arise from other sources.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:02:52