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Titolo:
Contributions of AMPA- and kainate-sensitive receptors to the photopic electroretinogram of the Xenopus retina
Autore:
Szikra, T; Witkovsky, P;
Indirizzi:
NYU, Sch Med, Dept Ophthalmol, New York, NY 10016 USA NYU New York NY USA10016 ch Med, Dept Ophthalmol, New York, NY 10016 USA NYU, Sch Med, Dept Physiol & Neurosci, New York, NY 10016 USA NYU New York NY USA 10016 Dept Physiol & Neurosci, New York, NY 10016 USA Lorand Eotvos Univ, Dept Neurobiol & Physiol, MTA ELTE Neurobiol Grp, Budapest, Hungary Lorand Eotvos Univ Budapest Hungary TE Neurobiol Grp, Budapest, Hungary Lorand Eotvos Univ, Dept Neurobiol & Physiol, Budapest, Hungary Lorand Eotvos Univ Budapest Hungary robiol & Physiol, Budapest, Hungary
Titolo Testata:
VISUAL NEUROSCIENCE
fascicolo: 2, volume: 18, anno: 2001,
pagine: 187 - 196
SICI:
0952-5238(200103/04)18:2<187:COAAKR>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOURCE-DENSITY ANALYSIS; B-WAVE; GLUTAMATE RECEPTORS; HORIZONTAL CELLS; BIPOLAR CELLS; RABBIT RETINA; KAINIC ACID; NEUROTOXIC ACTION; FIELD POTENTIALS; GOLDFISH RETINA;
Keywords:
kainate; AMPA; electroretinogram; Xenopus; excitotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Witkovsky, P NYU, Sch Med, Dept Ophthalmol, 550 1st Ave, New York, NY 10016 USA NYU 550 1st Ave New York NY USA 10016 New York, NY 10016 USA
Citazione:
T. Szikra e P. Witkovsky, "Contributions of AMPA- and kainate-sensitive receptors to the photopic electroretinogram of the Xenopus retina", VIS NEUROSC, 18(2), 2001, pp. 187-196

Abstract

The effects of kainate receptor-preferring glutamate were tested on the electroretinogram (ERG) of the: Xenopus retina. Kainate, domoic acid, and 5-iodowillardiine (20-100 muM) acted similarly in every respect. They increased peak amplitudes of the ERG a-, b-, and d-waves significantly over controls. The AMPA-specific antagonist, GYKI53655, prevented a kainate-induced increase in ERG a- and d-waves, but was without effect on an increase in the b-wave. Once the effect of agonist on the b-wave had peaked, the ERG began to subside, leading to its neatly complete disappearance within 20 min. Prior exposure to GYKI followed by a combination of GYKI + agonist did not significantly slow the rate of b-wave disappearance. Our results indicate that (1) AMPA receptors contribute to ERG a- and d-waves. (2) The kainate-evokedincrease in ERG (a-, b-, and d-waves probably results, in part, from an excitotoxic swellings of inner retinal processes. (3) The inner retina has a population of GYKI-resistant, kainate -sensitive receptors which may contribute to b-wave generation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:56:07