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Titolo:
Mental stress opposes endothelium-dependent vasodilation in young healthy individuals
Autore:
Sarabi, M; Lind, L;
Indirizzi:
Univ Uppsala Hosp, Dept Internal Med, S-75185 Uppsala, Sweden Univ UppsalaHosp Uppsala Sweden S-75185 al Med, S-75185 Uppsala, Sweden
Titolo Testata:
VASCULAR MEDICINE
fascicolo: 1, volume: 6, anno: 2001,
pagine: 3 - 7
SICI:
1358-863X(200102)6:1<3:MSOEVI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SILENT MYOCARDIAL ISCHEMIA; CORONARY-ARTERY DISEASE; ESSENTIAL-HYPERTENSION; FOREARM; RELAXATION; RESPONSES; HUMANS;
Keywords:
blood flow; endothelium; mental stress; nitric oxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Lind, L Univ Uppsala Hosp, Dept Internal Med, S-75185 Uppsala, Sweden UnivUppsala Hosp Uppsala Sweden S-75185 S-75185 Uppsala, Sweden
Citazione:
M. Sarabi e L. Lind, "Mental stress opposes endothelium-dependent vasodilation in young healthy individuals", VASC MED, 6(1), 2001, pp. 3-7

Abstract

Mental stress has been shown to induce myocardial ischemia in people with coronary heart disease (CHD), both in the laboratory and in daily life. In order to investigate the role of the endothelium in the regulation of bloodflow during stress, the endothelium-dependent (EDV) and endothelium-independent (EIDV) vasodilation was examined in the forearms of healthy people during a mental arithmetic test (MAT), a cold presser test ICP) and an isometric handgrip test (ISO). A total of 10 young healthy volunteers (four men and six women, aged 20-25 years) underwent measurements of forearm vascular resistance (FVR) during local intraarterial infusions of methacholine (MCh;inducing EDV) and sodium nitroprusside (SNP; inducing EIDV) at rest and during the different forms of stress by the use of venous occlusion plethysmography. MAT induced a significant increase in FVR during MCh infusion (4 mug/min, from 3.5 +/- 0.7 at rest to 4.2 +/- 1.4 mmHg/ml per min per 100 ml tissue during MAT; p < 0.01), while FVR during SNP infusion was unchanged byMAT. CP induced a significant increase in FVR during infusions with both MCh and SNP compared to resting levels (p < 0.01 for both), while ISO induced a significant increase in FVR during MCh infusion (p < 0.05) and a smaller increase in FVR during SNP infusion. When the SNP to MCh FVR ratio was used as an index of endothelial function, only MAT impaired endothelial function significantly (p < 0.01). In conclusion, mental stress induced by an arithmetic task selectively opposed EDV in the forearms of young healthy people, while cold presser and isometric handgrip tests induced a more general attenuation in vasodilatation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:48:10