Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cardiac mechanotransduction: from sensing to disease and treatment
Autore:
Tavi, P; Laine, M; Weckstrom, M; Ruskoaho, H;
Indirizzi:
Bioctr Oulu, Dept Physiol, Oulu, Finland Bioctr Oulu Oulu FinlandBioctr Oulu, Dept Physiol, Oulu, Finland Bioctr Oulu, Dept Phys Sci, Div Biophys, Oulu, Finland Bioctr Oulu Oulu Finland ulu, Dept Phys Sci, Div Biophys, Oulu, Finland Univ Oulu, Bioctr Oulu, Dept Pharmacol & Toxicol, FIN-90014 Oulu, Finland Univ Oulu Oulu Finland FIN-90014 acol & Toxicol, FIN-90014 Oulu, Finland Univ Helsinki, Cent Hosp, Dept Med, Helsinki 00029, Finland Univ HelsinkiHelsinki Finland 00029 , Dept Med, Helsinki 00029, Finland Minerva Inst, Helsinki 00029, Finland Minerva Inst Helsinki Finland 00029 inerva Inst, Helsinki 00029, Finland
Titolo Testata:
TRENDS IN PHARMACOLOGICAL SCIENCES
fascicolo: 5, volume: 22, anno: 2001,
pagine: 254 - 260
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; BRAIN NATRIURETIC PEPTIDE; RENIN-ANGIOTENSIN SYSTEM; STRETCH-INDUCED CHANGES; RAT ATRIAL MYOCYTES; HEART-FAILURE; IN-VIVO; TRANSCRIPTION FACTORS; VENTRICULAR MYOCYTES; SIGNALING PATHWAYS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Tavi, P Bioctr Oulu, Dept Physiol, Oulu, Finland Bioctr Oulu Oulu Finland octr Oulu, Dept Physiol, Oulu, Finland
Citazione:
P. Tavi et al., "Cardiac mechanotransduction: from sensing to disease and treatment", TRENDS PHAR, 22(5), 2001, pp. 254-260

Abstract

In heart muscle a mechanical stimulus is sensed and transformed into adaptive changes in cardiac function by a process called mechanotransduction. Adaptation of heart muscle to mechanical load consists of neurohumoral activation and growth, both of which decrease the initial load. Under prolonged overload this process becomes maladaptive, leading to the development of left ventricular hypertrophy end ultimately to heart failure. Widespread synergism end crosstalk among a variety of molecules and signals involved in hypertrophic signaling pathways make the prevention or treatment of left ventricular hypertrophy and heart failure a challenging task. Therapeutic strategies should include either a complete and continuous reduction of load or normalization of left ventricular mass by interventions aimed at specific targets involved in mechanotransduction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:19:55