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Titolo:
Receptor activator of nuclear factor kappa B ligand (RANKL): another link between breast and bone
Autore:
Martin, TJ; Gillespie, MT;
Indirizzi:
St Vincents Inst Med Res, Fitzroy, Vic 3065, Australia St Vincents Inst Med Res Fitzroy Vic Australia 3065 , Vic 3065, Australia
Titolo Testata:
TRENDS IN ENDOCRINOLOGY AND METABOLISM
fascicolo: 1, volume: 12, anno: 2001,
pagine: 2 - 4
SICI:
1043-2760(200101/02)12:1<2:RAONFK>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMARY-GLAND DEVELOPMENT; HORMONE-RELATED PROTEIN; OSTEOPROTEGERIN-LIGAND; OSTEOCLAST DIFFERENTIATION; MESSENGER-RNA; EXPRESSION; TISSUE; DESTRUCTION; CALCITONIN; PHYSIOLOGY;
Tipo documento:
News Item
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Martin, TJ St Vincents Inst Med Res, 9 Princes S, Fitzroy, Vic 3065, Australia St Vincents Inst Med Res 9 Princes S Fitzroy Vic Australia 3065
Citazione:
T.J. Martin e M.T. Gillespie, "Receptor activator of nuclear factor kappa B ligand (RANKL): another link between breast and bone", TRENDS ENDO, 12(1), 2001, pp. 2-4

Abstract

Mice rendered null for the genes encoding receptor activator of nuclear factor kappaB ligand (RANKL) or its receptor, RANK, are osteopetrotic becauseof failure of osteoclast development. The failure of lactation owing to the lack of development of lobulo-alveolar structures during pregnancy, despite earlier stages of mammary gland development being normal, is now added to each of these phenotypes. The breast phenotype in RANKL(-/-) (but not in RANK(-/-)) mice is rescued by treatment of pregnant mice with RANKL, indicating a key role for these tumour necrosis factor (TNF) ligand and receptor family members in a crucial terminal step in breast development and lactation. Both RANKL and RANK are synthesized by mammary epithelial cells. with both prolactin and parathyroid hormone-related protein (PTHrP) able to enhance production of mRNA for RANKL. These findings reveal a paracrine-autocrine system in lactation control, with novel signalling pathways that reflect intercellular communication processes in bone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 23:40:08