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Titolo:
Leptin in reproduction
Autore:
Caprio, M; Fabbrini, E; Isidori, AM; Aversa, A; Fabbri, A;
Indirizzi:
Univ La Sapienza, Dipartimento Fisiopatol Med, Cattedra Androl, I-00100 Rome, Italy Univ La Sapienza Rome Italy I-00100 Cattedra Androl, I-00100 Rome, Italy Univ Roma Tor Vergata, Dipartimento Med Interna, Cattedra Endocrinol, I-00133 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00133 Endocrinol, I-00133 Rome, Italy
Titolo Testata:
TRENDS IN ENDOCRINOLOGY AND METABOLISM
fascicolo: 2, volume: 12, anno: 2001,
pagine: 65 - 72
SICI:
1043-2760(200103)12:2<65:LIR>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; POLYCYSTIC-OVARY-SYNDROME; OBESE GENE-PRODUCT; SERUM LEPTIN; IN-VITRO; CIRCULATING LEPTIN; NEUROPEPTIDE-Y; LUTEINIZING-HORMONE; RECOMBINANT LEPTIN; ANTERIOR-PITUITARY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
95
Recensione:
Indirizzi per estratti:
Indirizzo: Caprio, M Univ La Sapienza, Dipartimento Fisiopatol Med, Cattedra Androl, I-00100 Rome, Italy Univ La Sapienza Rome Italy I-00100 ndrol, I-00100 Rome, Italy
Citazione:
M. Caprio et al., "Leptin in reproduction", TRENDS ENDO, 12(2), 2001, pp. 65-72

Abstract

In mammals, the function of the reproductive system is dependent on the availability of energy in the environment. It is well established that acute modifications of energy balance modulate the hypothalamic-pituitary-gonadalaxis. In several species, fasting and caloric restriction have been shown to cause the suppression of pulsatile luteinizing hormone secretion,via an inhibition of the gonadotropin-releasing hormone pulse generator. Such a mechanism probably prevents energy being wasted for reproduction. By contrast, excessive energy storage a nd obesity interfere with the correct regulation of the reproductive axis. The identification of leptin and leptin receptors, along with studies performed in animal models of leptin deficiency andresistance, has focused attention on the role of this molecule in reproduction, and disclosed new aspects of the relationship between energy stores, adipose tissue a nd reproductive function, Here, we discuss the central andperipheral effects of leptin on reproductive tissues, and try to fit a complex reality into a simplified model. In particular,the roles of leptin in reproduction at different anatomical levels and in various clinical and experimental settings are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 05:57:50