Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Novel glucocorticoid receptor coactivator effector mechanisms
Autore:
Jenkins, BD; Pullen, CB; Darimont, BD;
Indirizzi:
Univ Oregon, Inst Mol Biol, Eugene, OR 97403 USA Univ Oregon Eugene OR USA 97403 egon, Inst Mol Biol, Eugene, OR 97403 USA Univ Oregon, Dept Chem, Eugene, OR 97403 USA Univ Oregon Eugene OR USA 97403 v Oregon, Dept Chem, Eugene, OR 97403 USA
Titolo Testata:
TRENDS IN ENDOCRINOLOGY AND METABOLISM
fascicolo: 3, volume: 12, anno: 2001,
pagine: 122 - 126
SICI:
1043-2760(200104)12:3<122:NGRCEM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CREB-BINDING-PROTEIN; REGULATED GENE-EXPRESSION; RNA-POLYMERASE-II; NUCLEAR RECEPTOR; TRANSCRIPTIONAL ACTIVATION; STEROID-RECEPTORS; AGONIST ACTIVITY; IN-VIVO; KAPPA-B; COMPLEX;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Jenkins, BD Univ Oregon, Inst Mol Biol, Eugene, OR 97403 USA Univ Oregon Eugene OR USA 97403 ol Biol, Eugene, OR 97403 USA
Citazione:
B.D. Jenkins et al., "Novel glucocorticoid receptor coactivator effector mechanisms", TRENDS ENDO, 12(3), 2001, pp. 122-126

Abstract

Glucocorticoids regulate numerous distinct physiological processes, most of which rely on the ability of the hormone-bound glucocorticoid receptor (GR) to change the expression of target genes in a cell- and promoter-dependent manner. The transcriptional activity of GR depends on coactivators that regulate transcription by remodeling chromatin or by facilitating the recruitment of the basal transcriptional machinery. Coactivators are often part of multiprotein complexes that are not specific for GR but also mediate theactivity of other nuclear receptors (NRs) and unrelated transcription factors. Surprisingly, recent results reveal that the activity of coactivators might contribute to the receptor, promoter and cell specificity of NR action. The emerging picture shows coactivators as flexible, but precise, coordinators of complex and dynamic networks, in which transcriptional regulationby GR and other NRs is linked to other signaling pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:26:36