Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Rapid actions of plasma membrane estrogen receptors
Autore:
Kelly, MJ; Levin, ER;
Indirizzi:
Oregon Hlth Sci Univ, Sch Med, Dept Physiol & Pharmacol, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 rmacol, Portland, OR 97201 USA Univ Calif Irvine, Dept Med, Irvine, CA 92717 USA Univ Calif Irvine Irvine CA USA 92717 ine, Dept Med, Irvine, CA 92717 USA Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92717 USA Univ Calif IrvineIrvine CA USA 92717 ept Pharmacol, Irvine, CA 92717 USA Vet Affairs Med Ctr, Div Endocrinol, Long Beach, CA 90822 USA Vet Affairs Med Ctr Long Beach CA USA 90822 nol, Long Beach, CA 90822 USA
Titolo Testata:
TRENDS IN ENDOCRINOLOGY AND METABOLISM
fascicolo: 4, volume: 12, anno: 2001,
pagine: 152 - 156
SICI:
1043-2760(200105/06)12:4<152:RAOPME>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-COUPLED RECEPTORS; KAINATE-INDUCED CURRENTS; NITRIC-OXIDE SYNTHASE; PITUITARY-TUMOR CELLS; BREAST-CANCER CELLS; HIPPOCAMPAL-NEURONS; SIGNALING PATHWAYS; INDUCED ACTIVATION; KINASE PATHWAY; BINDING-SITES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Kelly, MJ Oregon Hlth Sci Univ, Sch Med, Dept Physiol & Pharmacol, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 rtland, OR 97201 USA
Citazione:
M.J. Kelly e E.R. Levin, "Rapid actions of plasma membrane estrogen receptors", TRENDS ENDO, 12(4), 2001, pp. 152-156

Abstract

Functional evidence for the existence of plasma membrane estrogen receptors in a variety of cell types continues to accumulate. Many of these functions originate from rapid signaling events, transduced in response to 17 beta-estradiol (E-2). It has been convincingly shown that E-2 activates phosphoinositol 3-kinase and protein kinase B/AKT, and stimulates ERK and p38 MAPkinases. In part, this stems from G-protein activation and the resulting calcium flux. As a result, the link between E-2 action at the cell membrane and discrete biological actions in the cell has been strengthened. There isnow convincing in vitro evidence that E-2 can modulate the functions of neural and vascular cells via non-genomic actions. Thus, the actions of discrete pools of E-2 receptors are likely to contribute to the overall effects of the sex steroids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:20:37