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Titolo:
Life-or-death decisions by the Bcl-2 protein family
Autore:
Adams, JM; Cory, S;
Indirizzi:
PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia PO Royal Melbourne Hosp Melbourne Vic Australia 3050 Vic 3050, Australia
Titolo Testata:
TRENDS IN BIOCHEMICAL SCIENCES
fascicolo: 1, volume: 26, anno: 2001,
pagine: 61 - 66
SICI:
0968-0004(200101)26:1<61:LDBTBP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; OUTER MITOCHONDRIAL-MEMBRANE; CYTOCHROME-C RELEASE; INTRACELLULAR-LOCALIZATION; CASPASE ACTIVATION; DEFICIENT MICE; BH3 DOMAIN; APOPTOSIS; BAX; SURVIVAL;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Adams, JM PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia PO Royal Melbourne Hosp Melbourne Vic Australia 3050 Australia
Citazione:
J.M. Adams e S. Cory, "Life-or-death decisions by the Bcl-2 protein family", TRENDS BIOC, 26(1), 2001, pp. 61-66

Abstract

In response to intracellular damage and certain physiological cues, cells enter the suicide program termed apoptosis, executed by proteases called caspases. Commitment to apoptosis is typically governed by opposing factions of the Bcl-2 family of cytoplasmic proteins, Initiation of the proteolytic cascade requires assembly of certain caspase precursors on a scaffold protein, and the Bcl-2 family determines whether this complex can form. Its pro-survival members can act by sequestering the scaffold protein and/or by preventing the release of apoptogenic molecules from organelles such as mitochondria. Pro-apoptotic family members act as sentinels for cellular damage: cytotoxic signals induce their translocation to the organelles where they bind to their pro-survival relatives, promote organelle damage and trigger apoptosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 02:01:59