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Titolo:
Signaling at zero G: G-protein-independent functions for 7-TM receptors
Autore:
Brzostowski, JA; Kimmel, AR;
Indirizzi:
NIH, Cellular & Dev Biol Lab, NIDDKD, Bethesda, MD 20892 USA NIH BethesdaMD USA 20892 & Dev Biol Lab, NIDDKD, Bethesda, MD 20892 USA
Titolo Testata:
TRENDS IN BIOCHEMICAL SCIENCES
fascicolo: 5, volume: 26, anno: 2001,
pagine: 291 - 297
SICI:
0968-0004(200105)26:5<291:SAZGGF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCHANGER REGULATORY FACTOR; METABOTROPIC GLUTAMATE RECEPTORS; POSTSYNAPTIC DENSITY PROTEINS; F9 TERATOCARCINOMA CELLS; II AT(1) RECEPTOR; BETA(2)-ADRENERGIC RECEPTOR; TYROSINE KINASE; BETA-ARRESTIN; CHEMOATTRACTANT RECEPTORS; COUPLED RECEPTORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Brzostowski, JA NIH, Cellular & Dev Biol Lab, NIDDKD, Bldg 10, Bethesda, MD 20892 USA NIH Bldg 10 Bethesda MD USA 20892 , Bethesda, MD 20892 USA
Citazione:
J.A. Brzostowski e A.R. Kimmel, "Signaling at zero G: G-protein-independent functions for 7-TM receptors", TRENDS BIOC, 26(5), 2001, pp. 291-297

Abstract

Eukaryotic cells, whether free-living, single-celled microbes or components of complex metazoa. can sense environmental cues through specialized seven-transmembrane (7-TM) receptors (also called heptahelical or G-protein-coupled receptors). 7-TM receptors detect 'inputs' such as light. peptide hormones, neurotransmitters, pheromones, odorants, morphogens and chemoattractants, linking extracellular stimuli to intracellular signaling networks via heterotrimeric G proteins. Recently, this obligatory paradigm has been challenged. A growing body of evidence indicates that 7-TM receptors can also transmit extracellular signals through mechanisms that function independently of G-protein coupling. This review discusses pathways and protein interactions for 7-TM receptors signaling 'at zero G' in Dictyostelium acid mammalian cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:55:20