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Titolo:
Post-prandial lipaemia and endothelial function among healthy men
Autore:
Muntwyler, J; Sutsch, G; Kim, JH; Schmid, H; Follath, F; Kiowski, W; Amann, FW;
Indirizzi:
Univ Zurich Hosp, Dept Internal Med, Div Cardiol, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Zurich Hosp, Inst Clin Chem, Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland Inst Clin Chem, Zurich, Switzerland
Titolo Testata:
SWISS MEDICAL WEEKLY
fascicolo: 15-16, volume: 131, anno: 2001,
pagine: 214 - 218
SICI:
1424-7860(20010421)131:15-16<214:PLAEFA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRIGLYCERIDE-RICH LIPOPROTEINS; CORONARY-ARTERY DISEASE; LOW-DENSITY-LIPOPROTEIN; NITRIC-OXIDE RELEASE; HIGH-FAT MEAL; HYPERCHOLESTEROLEMIC HUMANS; DEPENDENT VASODILATION; BETA-CAROTENE; ATHEROSCLEROSIS; METABOLISM;
Keywords:
triglycerides; chylomicrons; remnants; vascular function; lipoproteins; post-prandial; endothelium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Muntwyler, J Univ Zurich Hosp, Dept Internal Med, Div Cardiol, C-Hor 47,Ramistr 100, CH-8091 Zurich, Switzerland Univ Zurich Hosp C-Hor 47,Ramistr 100 Zurich Switzerland CH-8091
Citazione:
J. Muntwyler et al., "Post-prandial lipaemia and endothelial function among healthy men", SWISS MED W, 131(15-16), 2001, pp. 214-218

Abstract

Background: There is evidence that elevated post-prandial lipoproteins adversely affect progression and outcome of cardiovascular disease. Traditional risk factors are associated with impaired endothelium-mediated vasodilatation. However, studies regarding the relationship between post-prandial lipaemia and endothelial function are divergent. Methods: Twelve healthy non-smokers were included in this study. Before and after intake of a lipid cocktail rich in dairy fat, we tested endothelial-dependent (acetylcholine 0.8-160 mg/min per 100 mi forearm tissue) and -independent (sodium niuoprussid 0.6 mug/min) vascular function in the forearmvascular bed with plethysmography. Moreover, we tested the effect of l-NMMA, a competitive inhibitor of the NO synthetase, on baseline flow. Extent of post-prandial lipaemia was assessed with the increases in triglycerides and retinyl-palmitate, a marker for intestinally derived lipoproteins. Results: Baseline flow was higher after the test meal than during fasting (preprandial 6.5 +/- 0.5 ml/min* 100 mi tissue, post-prandial 8.0 +/- 0.5, p = 0.03), but similar after l-NMMA (p = 0.85). Before and after intake of the test meal, there was no significant difference in acetylcholine-inducedendothelium-dependent vasodilatation (repeated measurement ANOVA, p = 0.22). At the highest acetylcholine dose, forearm Row was very similar (fasting18.4 +/- 1.9, post-prandial 17.9 +/- 1.9, p = 0.75). At maximum acetylcholine dose, there was a weak inverse but non-significant correlation between forearm Row and post-prandial triglyceridaemia (r = -0.38, p = 0.23) and intestinally derived lipoproteins (chylomicrons r = -0.29, p = 0.35, chylomicron remnants r = -0.15, p = 0.63). However, at the lowest acetylcholine dose there was a suggestion for a positive correlation between change in flow and post-prandial lipaemia (triglyceridaemia, r = 0.53, p = 0.07; chylomicrons, r = 0.41, p = 0.18 and remnants, r = 0.51, p = 0.09). Endotheliurn-independent vasodilatation in response to sodium nitroprusside did not significantly change (p = 0.23). Conclusion: Our results suggest that among healthy men post-prandial lipaemia is not associated with a notable impairment of endothelium-mediated vascular function in forearm resistance vessels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 18:20:23