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Titolo:
Prospective evaluation of the systemic immune response following abdominal, vaginal, and laparoscopically assisted vaginal hysterectomy
Autore:
Malik, E; Buchweitz, O; Muller-Steinhardt, M; Kressin, P; Meyhofer-Malik, A; Diedrich, K;
Indirizzi:
Med Univ Lubeck, Dept Obstet & Gynecol, D-23538 Lubeck, Germany Med Univ Lubeck Lubeck Germany D-23538 Gynecol, D-23538 Lubeck, Germany Med Univ Lubeck, Dept Immunol, D-23538 Lubeck, Germany Med Univ Lubeck Lubeck Germany D-23538 Immunol, D-23538 Lubeck, Germany
Titolo Testata:
SURGICAL ENDOSCOPY-ULTRASOUND AND INTERVENTIONAL TECHNIQUES
fascicolo: 5, volume: 15, anno: 2001,
pagine: 463 - 466
SICI:
0930-2794(200105)15:5<463:PEOTSI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURGERY; INTERLEUKIN-6;
Keywords:
laparoscopically assisted vaginal hysterectomy; hysterectomy; surgical stress; cytokine; IL-6;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Malik, E Med Univ Lubeck, Dept Obstet & Gynecol, Ratzeburger Allee 160, D-23538 Lubeck, Germany Med Univ Lubeck Ratzeburger Allee 160 Lubeck GermanyD-23538 any
Citazione:
E. Malik et al., "Prospective evaluation of the systemic immune response following abdominal, vaginal, and laparoscopically assisted vaginal hysterectomy", SURG ENDOSC, 15(5), 2001, pp. 463-466

Abstract

Background: Alterations in serum levels of cytokine interleukin-6 (IL-6) and acute-phase protein C-reactive protein (CRP) correlate directly with extent of tissue damage and inflammatory reaction. We therefore prospectively com pared the postoperative levels of IL-6 and CRP following abdominal (AH), vaginal (VH), and laparoscopically assisted vaginal hysterectomy (LAVH). Methods: A total of 29 patients were included in the study (10 VH, 10 LAVH, 9 AH). Nine blood samples were taken from each patient at various time points before, during, and after surgery. CRP and IL-6 were measured under standardized conditions using ELISA and turbidometry. Results: Preoperative levels of IL-6 and CRP were low in all three patientgroups. There was a significant increase in the IL-6 level in patients undergoing AH at the time of peritoneal closure that reached a maximum 2 h postoperatively and remained significantly elevated for 12 h postoperatively when compared to the IL-6 levels of patients undergoing VH or LAVH (p < 0.05). The levels of the IL-6 time courses differed significantly among the three operative procedures (p = 0.013). In contrast, the levels of the CRP time courses did not differ significantly (p = 0.066) however, CRP expression was elevated 36 h postoperatively in patients undergoing AH, as compared with those undergoing VH. Conclusion: Elevated IL-6 levels subsequent to AH may reflect significantly greater tissue damage in these patients than in patients who undergo VH or LAVH. LAVH should therefore be considered in cases that cannot be managedby the vaginal route alone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 13:01:10