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Titolo:
Cortical neurogenesis in adult rats after transient middle cerebral arteryocclusion
Autore:
Jiang, W; Gu, WG; Brannstrom, T; Rosqvist, R; Wester, P;
Indirizzi:
Umea Univ, Dept Publ Hlth & Clin Med, Umea Stroke Ctr, Res Lab UKBF 5B, SE-90187 Umea, Sweden Umea Univ Umea Sweden SE-90187 r, Res Lab UKBF 5B, SE-90187 Umea, Sweden Umea Univ, Umea Stroke Ctr, Dept Med, SE-90187 Umea, Sweden Umea Univ Umea Sweden SE-90187 roke Ctr, Dept Med, SE-90187 Umea, Sweden Umea Univ, Umea Stroke Ctr, Dept Med Biosci, SE-90187 Umea, Sweden Umea Univ Umea Sweden SE-90187 r, Dept Med Biosci, SE-90187 Umea, Sweden Umea Univ, Umea Stroke Ctr, Dept Pathol, SE-90187 Umea, Sweden Umea Univ Umea Sweden SE-90187 e Ctr, Dept Pathol, SE-90187 Umea, Sweden Umea Univ, Umea Stroke Ctr, Dept Cell & Mol Biol, SE-90187 Umea, Sweden Umea Univ Umea Sweden SE-90187 pt Cell & Mol Biol, SE-90187 Umea, Sweden
Titolo Testata:
STROKE
fascicolo: 5, volume: 32, anno: 2001,
pagine: 1201 - 1207
SICI:
0039-2499(200105)32:5<1201:CNIARA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; NEURAL STEM-CELLS; DENTATE GYRUS; PROLIFERATION; HIPPOCAMPUS; FOREBRAIN; NEURONS; PROGENITORS; NEOCORTEX; MIGRATION;
Keywords:
bromodeoxyuridine; cerebral ischemia; middle cerebral artery occlusion; neurons; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Wester, P Umea Univ, Dept Publ Hlth & Clin Med, Umea Stroke Ctr, Res Lab UKBF 5B, SE-90187 Umea, Sweden Umea Univ Umea Sweden SE-90187 UKBF 5B, SE-90187 Umea, Sweden
Citazione:
W. Jiang et al., "Cortical neurogenesis in adult rats after transient middle cerebral arteryocclusion", STROKE, 32(5), 2001, pp. 1201-1207

Abstract

Background and Purpose-This study explored the possible occurrence of newly generated nerve cells in the ischemic cortex of adult rats after middle cerebral artery occlusion and reperfusion. Methods-Nine- to 10-week-old male Wistar rats were subjected to 2 hours ofmiddle cerebral artery occlusion by the monofilament method. Rats receivedrepeated intraperitoneal injections of the cell proliferation-specific marker 5-bromodeoxyuridine (BrdU) after stroke induction. Brain sections were processed for immunohistochemistry with an avidin-biotin complex-alkaline phosphatase and/or -peroxidase method. Brain sections processed with double-immunofluorescent staining were further scanned by confocal microscopy. Results-Interspersed among the predominantly newly formed glial cells, some cells were double labeled by BrdU and 1 of the neuron-specific markers, Map-2, beta -tubulin III, and Neu N, at 30 and 60 days after stroke onset. These cells were randomly distributed throughout cortical layers II through VI, occurring with highest density in the ischemic boundary zone. Three-dimensional confocal analyses of BrdU and the neuron-specific marker Neu N confirmed their colocalization within the same cortical cells. Conclusions-This study suggests that new neurons can be generated in the cerebral cortex of adult rats after transient focal cerebral ischemia. Cortical neurogenesis may be a potential pathway for brain repair after stroke.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:15:08