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Titolo:
Elevated plasma homocysteine levels and risk of silent brain infarction inelderly people
Autore:
Matsui, T; Arai, H; Yuzuriha, T; Yao, H; Miura, M; Hashimoto, S; Higuchi, S; Matsushita, S; Morikawa, M; Kato, A; Sasaki, H;
Indirizzi:
Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 ed, Sendai, Miyagi 9808574, Japan Hizen Natl Hosp, Ctr Emot & Behav Disorders, Saga, Japan Hizen Natl Hosp Saga Japan osp, Ctr Emot & Behav Disorders, Saga, Japan Kyushu Univ, Dept Internal Med 2, Fukuoka 812, Japan Kyushu Univ FukuokaJapan 812 v, Dept Internal Med 2, Fukuoka 812, Japan Mitsubishi Kagaku Bioclin Labs Inc, Res & Dev, Tokyo, Japan Mitsubishi Kagaku Bioclin Labs Inc Tokyo Japan Res & Dev, Tokyo, Japan Kurihama Natl Hosp, Dept Psychiat, Kanagawa, Japan Kurihama Natl Hosp Kanagawa Japan Hosp, Dept Psychiat, Kanagawa, Japan Sendai City Med Ctr, Dept Cardiol, Sendai, Miyagi, Japan Sendai City Med Ctr Sendai Miyagi Japan t Cardiol, Sendai, Miyagi, Japan
Titolo Testata:
STROKE
fascicolo: 5, volume: 32, anno: 2001,
pagine: 1116 - 1119
SICI:
0039-2499(200105)32:5<1116:EPHLAR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL INFARCTION; VASCULAR-DISEASE; METHYLENETETRAHYDROFOLATE REDUCTASE; HORDALAND HOMOCYSTEINE; WHITE-MATTER; SERUM; LESIONS; FOLATE;
Keywords:
homocyst(e)ine; lacunar infarction; magnetic resonance imaging; risk factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Arai, H Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 ai, Miyagi 9808574, Japan
Citazione:
T. Matsui et al., "Elevated plasma homocysteine levels and risk of silent brain infarction inelderly people", STROKE, 32(5), 2001, pp. 1116-1119

Abstract

Background and Purpose-Silent brain infarction (SBI) on MRI is common in elderly people, and recent studies have demonstrated that SBI increases the risk of progression to clinically apparent stroke and cognitive decline. Therefore, an early and accurate detection of SBI and a search for potential treatable risk factors may have a significant impact on public health. Methods-Community-dwelling elderly people aged greater than or equal to 66years who participated in the present study (n=153) underwent brain MRI and standardized physical and neuropsychological examinations as well as blood biochemistry determinations, including total plasma homocysteine (pHcy), renal function, vitamin status, and polymorphisms of the methylenetetrahydrofolate reductase gene. Results-SBI was found in 24.8% of the participants. In the univariate analysis, the pHcy levels in subjects with SBI (13.6 +/-4.1 mu mol/L) were significantly higher (P=0.0004) than those in subjects without SBI (11.0 +/-3.3mu mol/L). When pHcy levels were stratified into high (greater than or equal to 15.1 mmol/L), moderate (11.6 to 15.0 mmol/L), and low (less than or equal to 11.5 mmol/L) groups, age (P <0.0001), male sex (P <0.0001), the habits of cigarette smoking (P <0.0001) and of alcohol consumption (P=0.0002),and folate levels (P=0.01) were significantly associated with an elevationof pHcy levels. The elevated pHcy levels were significantly associated with SBI after individual adjustment for age, sex, hypertension, renal function, and the habits of smoking and alcohol consumption. Conclusions-pHcy level is associated with age and nutritional and other lifestyle factors, and it contributes to a risk for SBI.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:00:31