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Titolo:
The efficacy of direct current stimulation for lumbar intertransverse process fusions in an animal model
Autore:
France, JC; Norman, TL; Santrock, RD; McGrath, B; Simon, BJ;
Indirizzi:
W Virginia Univ, Dept Orthoped, Morgantown, WV 26506 USA W Virginia Univ Morgantown WV USA 26506 rthoped, Morgantown, WV 26506 USA W Virginia Univ, Dept Mech & Aerosp Engn, Morgantown, WV 26506 USA W Virginia Univ Morgantown WV USA 26506 sp Engn, Morgantown, WV 26506 USA SUNY Buffalo, Dept Orthoped, New York, NY USA SUNY Buffalo New York NY USA NY Buffalo, Dept Orthoped, New York, NY USA EBI Med Syst, Parsippany, NJ USA EBI Med Syst Parsippany NJ USAEBI Med Syst, Parsippany, NJ USA
Titolo Testata:
SPINE
fascicolo: 9, volume: 26, anno: 2001,
pagine: 1002 - 1007
SICI:
0362-2436(20010501)26:9<1002:TEODCS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINAL-FUSION; ELECTROMAGNETIC-FIELDS; ARTHRODESIS; ALLOGRAFT; FIXATION; PROTEIN;
Keywords:
animal model; bone graft; DC electrical stimulation; spinal fusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: France, JC W Virginia Univ, Dept Orthoped, Morgantown, WV 26506 USA W Virginia Univ Morgantown WV USA 26506 rgantown, WV 26506 USA
Citazione:
J.C. France et al., "The efficacy of direct current stimulation for lumbar intertransverse process fusions in an animal model", SPINE, 26(9), 2001, pp. 1002-1007

Abstract

Study Design. Posterolateral lumbar intertransverse process fusion using arabbit model with autologous bone graft and direct current stimulation wascompared with fusion achieved by using autologous bone graft alone. Objectives. To determine the efficacy of direct current electrical stimulation for the posterolateral lumbar intertransverse process fusion techniqueby using a 20-muA current and the more recently developed 60-muA current delivered by an implantable direct current stimulator. Summary of Background Data. Previous studies have demonstrated a positive effect of direct current electrical stimulation on posterior spinal fusion techniques. However, until recently, the environment of an intertransverse fusion was not well simulated. The current research examined the posterolateral lumbar intertransverse process fusion technique with direct current electrical stimulation using a rabbit model. This appears to parallel human fusion techniques more closely and allows for lower cost and technical ease. Methods. In this study, 44 adult New Zealand white rabbits underwent an L5-L6 intertransverse process fusion. All the fusions used an autologous bonegraft obtained from bilateral posterior iliac crests. A device was implanted in all the rabbits subcutaneously, and they were divided randomly into three groups: a sham or non-functioning group, a 20-muA low-current stimulator group, and a 60-muA higher-current stimulator group. Spinal fusion was evaluated radiographically, histologically, and manually as well as by biomechanical testing 5 weeks after surgery. Results. Radiographic grades, manual palpation, biomechanical strength, and stiffness showed an increasing trend from sham or inactive stimulator groups to low-current and then to high-current stimulator groups. Histologic analysis revealed that the higher-current stimulator showed that, statistically, the healing response of the host tissue to the autograft had increasedsignificantly, as compared with the sham. Conclusions. Direct current electrical stimulation is efficacious in improving both the healing rate and strength in this posterolsteral lumbar fusion model. In addition, it appears that this effect is enhanced by increasingthe stimulation current from 20 muA to 60 pA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:51:37