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Titolo:
Multivariate analysis of genetic and acquired factors; T235 variant of theangiotensinogen gene is a potent independent risk factor for preeclampsia
Autore:
Kobashi, G; Shido, K; Hata, A; Yamada, H; Kato, EH; Kanamori, M; Fujimoto, S; Kondo, K;
Indirizzi:
Hokkaido Univ, Dept Prevent Med, Grad Sch Med, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan Hokkaido Univ, Dept Obstet & Gynecol, Grad Sch Med, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan Hamamatsu Univ, Sch Med, Dept Publ Hlth, Hamamatsu, Shizuoka 43131, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 43131 atsu, Shizuoka 43131, Japan Univ Air, Chiba 260, Japan Univ Air Chiba Japan 260Univ Air, Chiba 260, Japan
Titolo Testata:
SEMINARS IN THROMBOSIS AND HEMOSTASIS
fascicolo: 2, volume: 27, anno: 2001,
pagine: 143 - 147
SICI:
0094-6176(2001)27:2<143:MAOGAA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESSENTIAL-HYPERTENSION; BLOOD-PRESSURE; PREGNANCY;
Keywords:
preeclampsia; multivariate analysis; lifestyle; angiotensinogen; polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Kobashi, G Hokkaido Univ, Dept Prevent Med, Grad Sch Med, N15 W7, Sapporo,Hokkaido 0608638, Japan Hokkaido Univ N15 W7 Sapporo Hokkaido Japan 0608638 8638, Japan
Citazione:
G. Kobashi et al., "Multivariate analysis of genetic and acquired factors; T235 variant of theangiotensinogen gene is a potent independent risk factor for preeclampsia", SEM THROMB, 27(2), 2001, pp. 143-147

Abstract

Preeclampsia is known to be a multifactorial disease. Recently, the angiotensinogen gene has been shown to be a candidate gene that could be related to preeclampsia, and acquired factors such as lifestyle during pregnancy have also been considered to be risk factors. The aim of this study was to investigate the interrelations among the angiotensinogen gene and various acquired risk factors in preeclampsia. Fifty-eight primiparous patients with preeclampsia were compared with 164 normal primiparous controls. A variant of the an giotensinogen gene (M235T) was analyzed along with the acquired factors obtained fi-om both medical records and a questionnaire consisting of98 questions. Univariate analysis disclosed 11 factors that were significantly associated with preeclampsia (P < .05). Multivariate analysis revealedfour significant independent factors: "prepregnancy high body mass (body mass index greater than or equal to 24)," "T235 homozygotes of the angiotensinogen gene," "mentally stressful condition during pregnancy," and "salty dishes preferred during pregnancy. " The odds ratios of the four factors were6.2, 2.5, 3.0 and 2.6, respectively in a multiple logistic model. Our results support the concept that T235 of the angiotensinogen gene is a potent, independent risk factor for preeclampsia, as well as other lifestyle-related risk factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 15:31:24