Catalogo Articoli (Spogli Riviste)

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Titolo:
Recurrent pregnancy loss: Etiology of thrombophilia
Autore:
Yamada, H; Kato, EH; Kobashi, G; Ebina, Y; Shimada, S; Morikawa, M; Yamada, T; Sakuragi, N; Fujimoto, S;
Indirizzi:
Hokkaido Univ, Sch Med, Dept Obstet & Gynecol, Kita Ku, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan Hokkaido Univ, Sch Med, Dept Hlth Senior Citizens, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan
Titolo Testata:
SEMINARS IN THROMBOSIS AND HEMOSTASIS
fascicolo: 2, volume: 27, anno: 2001,
pagine: 121 - 129
SICI:
0094-6176(2001)27:2<121:RPLEOT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-XII-DEFICIENCY; FACTOR-V-LEIDEN; ACTIVATED PROTEIN-C; SYSTEMIC LUPUS-ERYTHEMATOSUS; ANTITHROMBIN-III DEFICIENCY; HEPATOCYTE GROWTH-FACTOR; COAGULATION FACTOR-XII; ANTICARDIOLIPIN ANTIBODIES; METHYLENETETRAHYDROFOLATE REDUCTASE; MYOCARDIAL-INFARCTION;
Keywords:
thrombophilia; factor V Leiden mutation; methylene tetrahydrofolate reductase; antiphospholipid antibody; abortion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Yamada, H Hokkaido Univ, Sch Med, Dept Obstet & Gynecol, Kita Ku, N-15 W7,Sapporo, Hokkaido 0608638, Japan Hokkaido Univ N-15 W7 Sapporo Hokkaido Japan 0608638 8638, Japan
Citazione:
H. Yamada et al., "Recurrent pregnancy loss: Etiology of thrombophilia", SEM THROMB, 27(2), 2001, pp. 121-129

Abstract

Congenital and acquired thrombophilia are associated with an increased risk of pregnancy-associated venous thrombosis and fetal loss. Two hundred eighty-nine patients with a history of recurrent spontaneous abortion were subjected to screening examinations for the etiology of these abortions. Endocrine abnormality (28.0%), uterine abnormality (10.4%), autoimmune diseases (1.4%), antiphospholipid antibody syndrome (4.5%), and balanced type chromosome translocation (4.2%) were found as underlying causes of recurrent abortions, and the remaining 55.0% of the 289 patients were classified as having an unexplained etiology. Congenital thrombophilia such as protein C (PC) deficiency, protein S (PS) deficiency, antithrombin deficiency, and factor V Leiden mutation was not frequently detected; only one patient had PS deficiency. A reduced factor XII activity was found at a frequency of 4.2%. Thefrequency of methylene tetrahydrofolate reductase gene C677T mutation in recurrent aborters (0.38) was the same as that found in a fertile control group. Although the prevalence of anti-beta2-glycoprotein I antibody (a beta2-GPI) syndrome was very low (1.7%), patients with a high titer of immunoglobulin G (IgG) class a beta2-GPI, despite anticoagulation therapy, experienced severe fetomaternal complications in subsequent pregnancies. The rate (13.8%) of positive tests for serum IgA class a beta2-GPI in patients with unexplained etiology was higher than that in the controls (0%) (P < .05). We conclude that congenital thrombophilia is rare in Japanese patients who hadexperienced consecutive spontaneous abortions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:10:22