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Titolo:
Is factor XII deficiency related to recurrent miscarriage?
Autore:
Matsuura, T; Kobayashi, T; Asahina, T; Kanayama, N; Terao, T;
Indirizzi:
Hamamatsu Univ, Sch Med, Dept Obstet & Gynecol, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 , Shizuoka 4313192, Japan
Titolo Testata:
SEMINARS IN THROMBOSIS AND HEMOSTASIS
fascicolo: 2, volume: 27, anno: 2001,
pagine: 115 - 120
SICI:
0094-6176(2001)27:2<115:IFXDRT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREGNANCY; ANTIBODIES; PREVALENCE; ABORTION; WOMEN;
Keywords:
factor XII deficiency; miscarriage; kinin formation; postpartum bleeding; uterine contraction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Kobayashi, T Hamamatsu Univ, Sch Med, Dept Obstet & Gynecol, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 13192, Japan
Citazione:
T. Matsuura et al., "Is factor XII deficiency related to recurrent miscarriage?", SEM THROMB, 27(2), 2001, pp. 115-120

Abstract

Factor XII (FXII) is an important protease that plays a major role in the initiation of the intrinsic pathway of blood coagulation. Although congenital FXII deficiency is not associated with a clinical bleeding tendency, it can be identified on a routine coagulation test, such as a prolonged activated partial thromboplastin time. This deficiency is a rare autosomal recessive disorder. It is still unclear whether FXII deficiency causes any disorders during pregnancy. Recurrent miscarriages and placental abruption were reported in cases with FXII deficiency. We successfully treated a woman whose pregnancy was complicated by congenital FXII deficiency. We report her clinical courses of gestation, delivery, and puerperium and discuss the role of maternal FXII associated with pregnancy. In our case, courses of gestation and delivery were normal. Postpartum uterine bleeding was, however, prolonged due to a subinvolution of the puerperal uterus. Our results indicate that, except for postpartum uterine contraction, FXII does not play a majorrole in gestation and delivery. We suggest that FXII deficiency is not associated with recurrent miscarriage and that normal gestation and vaginal delivery are possible even in cases with congenital FXII deficiency. We assert that the possible correlation of FXII deficiency with recurrent miscarriage merits reevaluation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 18:52:32