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Titolo:
Towards a mechanistic understanding of tumor invasion - lessons from the alpha 6 beta 4 integrin
Autore:
Mercurio, AM; Rabinovitz, I;
Indirizzi:
Beth Israel Deaconess Med Ctr, Dept Pathol, Div Canc Biol & Angiogenesis, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr Boston MA USA 02215 s, Boston, MA 02215 USA Harvard Univ, Sch Med, Boston, MA 02215 USA Harvard Univ Boston MA USA 02215 vard Univ, Sch Med, Boston, MA 02215 USA
Titolo Testata:
SEMINARS IN CANCER BIOLOGY
fascicolo: 2, volume: 11, anno: 2001,
pagine: 129 - 141
SICI:
1044-579X(200104)11:2<129:TAMUOT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
3-DIMENSIONAL COLLAGEN LATTICES; EPIDERMAL GROWTH-FACTOR; CARCINOMA-CELLS; E-CADHERIN; ALPHA(6)BETA(4) INTEGRIN; EXTRACELLULAR-MATRIX; ARP2/3 COMPLEX; CHEMOTACTIC MIGRATION; SIGNAL-TRANSDUCTION; CANCER PROGRESSION;
Keywords:
invasion; cancer; integrin; signaling; cytoskeleton;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
103
Recensione:
Indirizzi per estratti:
Indirizzo: Mercurio, AM Beth Israel Deaconess Med Ctr, Dept Pathol, Div Canc Biol & Angiogenesis, 330 Brookline Ave, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr 330 Brookline Ave Boston MA USA 02215
Citazione:
A.M. Mercurio e I. Rabinovitz, "Towards a mechanistic understanding of tumor invasion - lessons from the alpha 6 beta 4 integrin", SEM CANC B, 11(2), 2001, pp. 129-141

Abstract

This review explores the mechanistic basis of carcinoma migration and invasion by focusing on the contribution of integrins. Integrins are essential for invasion not only for their ability to mediate physical interactions with extracellular matrices, but also for their ability to regulate signalingpathways that control actin dynamics and cell movement, as well as for growth and survival. Our comments center on a unique member of the integrin family, the alpha6 beta4 integrin, which is a receptor for the laminin familyof basement membrane components. Numerous studies have implicated this integrin in the invasion of solid tumors and have provided a rationale for studying the mechanistic basis of its contribution to the invasive process. Such studies have revealed novel insights into the mechanism of carcinoma invasion that involve both the dynamics of cell migration and signaling pathways that regulate this migration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:12:07