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Titolo:
A randomized open-label study of gabapentin and lamotrigine in adults withlearning disability and resistant epilepsy
Autore:
Crawford, P; Brown, S; Kerr, M;
Indirizzi:
Univ Plymouth, Dev Disabil Res & Educ Grp, Plymouth PL4 8AA, Devon, England Univ Plymouth Plymouth Devon England PL4 8AA outh PL4 8AA, Devon, England Welsh Ctr Learning Disabil, Cardiff, S Glam, Wales Welsh Ctr Learning Disabil Cardiff S Glam Wales , Cardiff, S Glam, Wales Parke Davis, Eastleigh, England Parke Davis Eastleigh EnglandParke Davis, Eastleigh, England York Dist Hosp, Dept Neurosci, York YO3 7HE, N Yorkshire, England York Dist Hosp York N Yorkshire England YO3 7HE 7HE, N Yorkshire, England
Titolo Testata:
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
fascicolo: 2, volume: 10, anno: 2001,
pagine: 107 - 115
SICI:
1059-1311(200103)10:2<107:AROSOG>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
LENNOX-GASTAUT-SYNDROME; MENTAL-RETARDATION; PEOPLE;
Keywords:
epilepsy; learning disabilities; mental retardation; gabapentin; lamotrigine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Crawford, P York Dist Hosp, Dept Neurosci, Wigginton Rd, York YO31 8HE, N Yorkshire, England York Dist Hosp Wigginton Rd York N Yorkshire England YO31 8HE
Citazione:
P. Crawford et al., "A randomized open-label study of gabapentin and lamotrigine in adults withlearning disability and resistant epilepsy", SEIZURE-E J, 10(2), 2001, pp. 107-115

Abstract

The aim of this study was to evaluate the efficacy and safety of gabapentin in patients with learning disabilities and resistant epilepsy, comparing the effects of gabapentin with lamotrigine on efficacy, behaviour and mood. An open-label, randomized, parallel group, multicentre add-on study comparing gabapentin with lamotrigine in 109 patients with drug-resistant localization-related epilepsy and learning disabilities was conducted: 39 patientswere randomized to gabapentin and 44 to lamotrigine. The study population had a range of learning disabilities and severe partial epilepsy. The percentage of patients achieving a greater than or equal to 50% reduction in seizure frequency on gabapentin was 50%, (mean reduction in seizureswas 51%). Compared to 48.6% of lamotrigine patients, no statistically significant treatment differences could be identified. The safely profile of both drugs was consistent with that seen in previous clinical trials. Carerrated visual analogue scales detected significant improvements (P < 0.05) forthe gabapentin-treated patients in seizure severity, attention, general health and sleeping pattern, while for lamotrigine seizure severity improved significantly. For learning disabled patients with resistant epilepsy, gabapentin and lamotrigine provide safe and effective treatment, with positive benefits on behaviour. (C) 2001 BEA Trading Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:26:54