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Titolo:
Increased FiO(2) improves intrathecal oxygenation during thoracic aortic cross-clamping in pigs
Autore:
Christiansson, L; Ulus, AT; Hellberg, A; Bergqvist, D; Wiklund, L; Karacagil, S;
Indirizzi:
Univ Hosp, Dept Anesthesiol, SE-75185 Uppsala, Sweden Univ Hosp Uppsala Sweden SE-75185 Anesthesiol, SE-75185 Uppsala, Sweden Univ Hosp, Dept Surg, SE-75185 Uppsala, Sweden Univ Hosp Uppsala Sweden SE-75185 p, Dept Surg, SE-75185 Uppsala, Sweden
Titolo Testata:
SCANDINAVIAN CARDIOVASCULAR JOURNAL
fascicolo: 2, volume: 35, anno: 2001,
pagine: 147 - 150
SICI:
1401-7431(200103)35:2<147:IFIIOD>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINAL-CORD ISCHEMIA; BLOOD-FLOW; PERFUSION; TENSION; BRAIN; OCCLUSION; PRESSURE; SURFACE; PO(2); PH;
Keywords:
aortic clamping; fraction of inspired oxygen; hypoperfusion; intrathecal oxygenation; perfusion pressure; spinal cord ischemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Christiansson, L Univ Hosp, Dept Anesthesiol, SE-75185 Uppsala, Sweden Univ Hosp Uppsala Sweden SE-75185 75185 Uppsala, Sweden
Citazione:
L. Christiansson et al., "Increased FiO(2) improves intrathecal oxygenation during thoracic aortic cross-clamping in pigs", SC CARDIOVA, 35(2), 2001, pp. 147-150

Abstract

Objectives-To investigate the effect of 100% oxygen ventilation on cerebrospinal fluid (CSF) oxygenation in I I pigs during thoracic aortic cross-clamping. Design-An aorto-aortic shunt was used for control of central hemodynamics and study of hypoperfusion by exsanguination. CSF PO2, PCO2 and pH were continuously monitored before and during clamping, The changes in hemodynamic parameters and intrathecal gas tensions in response to variations in proximal mean aortic pressure and fraction of inspired oxygen (FiO(2)) were recorded. Results-Baseline CSF PO2 decreased from 4.8 +/- 1.9 to 2.6 +/- 2.2 kPa following aortic occlusion, Increasing FiO(2) to 1.0 resulted in a significantincrease in CSF PO2 to 4.1 +/- 3.0 with a return to 2.7 +/- 2.1 kPa after reducing FiO(2) to 0.4 again. The same variations in FiO(2) did not induce any significant changes in CSF PO2 during hypotension. Conclusion-Increased FiO(2) during experimental thoracic aortic cross-clamping with stable proximal arterial pressure helps to maintain CSF PO2, whereas severe hypotension could not be compensated for by hyperoxemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:28:58