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Titolo:
Cytokine responses in patients undergoing coronary artery bypass surgery after ischemic preconditioning
Autore:
Wei, MX; Kuukasjarvi, P; Laurikka, J; Pehkonen, E; Kaukinen, S; Laine, S; Tarkka, M;
Indirizzi:
Tampere Univ Hosp, Div Cardiovasc Surg, FI-33521 Tampere, Finland Tampere Univ Hosp Tampere Finland FI-33521 rg, FI-33521 Tampere, Finland Tampere Univ Hosp, Dept Anesthesia & Intens Care, FI-33521 Tampere, Finland Tampere Univ Hosp Tampere Finland FI-33521 re, FI-33521 Tampere, Finland Tampere Univ Hosp, Dept Clin Chem, FI-33521 Tampere, Finland Tampere Univ Hosp Tampere Finland FI-33521 em, FI-33521 Tampere, Finland
Titolo Testata:
SCANDINAVIAN CARDIOVASCULAR JOURNAL
fascicolo: 2, volume: 35, anno: 2001,
pagine: 142 - 146
SICI:
1401-7431(200103)35:2<142:CRIPUC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOPULMONARY BYPASS; PROINFLAMMATORY CYTOKINES; MYOCARDIUM; RELEASE; INJURY; METHYLPREDNISOLONE; INTERLEUKIN-6; REPERFUSION;
Keywords:
cytokines; ischemic preconditioning; coronary artery bypass grafting;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Tarkka, M Tampere Univ Hosp, Div Cardiovasc Surg, POB 2000, FI-33521 Tampere, Finland Tampere Univ Hosp POB 2000 Tampere Finland FI-33521 re, Finland
Citazione:
M.X. Wei et al., "Cytokine responses in patients undergoing coronary artery bypass surgery after ischemic preconditioning", SC CARDIOVA, 35(2), 2001, pp. 142-146

Abstract

Objective-The release of proinflammatory cytokines has been shown to be associated with the development of complications after coronary artery bypassgrafting with cardiopulmonary bypass. The purpose of the present study wasto establish whether ischemic preconditioning (IP) could limit inflammatory cytokines release in patients undergoing elective coronary artery bypass surgery. Methods-Twenty-two patients with multiple-vessel coronary artery disease and stable angina admitted for first-time elective coronary artery bypass surgery were randomized into control or ischemic preconditioning groups. Patients in the IP group were exposed to two cycles of two-minute myocardial ischemia, followed by three minutes of reperfusion, at the beginning of the revascularization operation, before the cross-clamping and ischemic period used for coronary artery bypass graft anastomosis. Peripheral plasma levels of TNF-alpha, IL-6, IL-8 and IL-IO were measured perioperatively. Results-Significant elevation of IL-6, IL-8 and IL-IO were observed in both groups after reperfusion. Ischemic preconditioning has no effect on cytokine release in the early stage after reperfusion. Arterial blood IL-6 levels in the preconditioning group were significantly lower than in controls at20 h after declamping (52.93 +/- 9.79 vs 96.04 +/- 17.56 pg/ml, p < 0.05),Conclusions-The results indicate that ischemic preconditioning results in no effect on systemic inflammatory cytokine release in the early stage but a delayed reduction in IL-6 levels at 20 h after reperfusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 06:59:52